Study of Occupational Chromium, Iron, and Nickel Exposure and Amyotrophic Lateral Sclerosis in Denmark
Bibliographic Data
| ID | 15504381 |
|---|---|
| Authors | Aisha S Dickerson (0000-0003-3929-9540, Johns Hopkins University, corresponding author), Johnni Hansen (0000-0002-9342-2725, Danish Cancer Society), Ole Gredal (National Rehabilitation Center for Neuromuscular Disorders, 8000 Copenhagen, Denmark), Marc G Weisskopf (0000-0003-4513-9834, Harvard University) |
| Year | 2020 |
| Volume | 17 |
| Issue | 21 |
| Pages | 8086-8086 |
| Publication date | 2020-11-02 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph17218086 |
| PMID | 33147887 |
| OpenAlex | W3095897561 |
| Language | EN |
| References cited | 48 |
Studies of occupational metal exposures and amyotrophic lateral sclerosis (ALS) have focused primarily on known neurotoxicants, including lead, mercury, selenium, and cadmium. However, these exposures are often co-occurring with other lesser studied metals. We conducted a population-based case-control study with the aim of assessing associations between occupational chromium, iron, and nickel exposures and risk of ALS. We identified ALS cases in Denmark from 1982 through 2013 from the Danish National Patient Registry and matched them to 100 controls based on birth year and sex. Cumulative metal exposures were estimated using job exposure matrices applied to occupational history from the Danish Pension Fund. Although mutually adjusted odds of ALS were higher in men with chromium exposures in the third quartile (aOR = 1.24; 95% CI 0.91, 1.69) and fourth quartile (aOR = 1.19; 95% CI: 0.80, 1.76) compared to those with no exposure, differences did not reach statistical significance. We also observed higher odds of ALS in women with nickel exposures in the third quartile (aOR = 2.21; 95% CI: 1.14, 4.28), but not for the fourth quartile (aOR = 0.61; 95% CI: 0.23, 1.64). Our findings do not suggest associations between occupational exposures to these metals and ALS. However, unavoidable non-differential misclassification from the use of JEMs may have masked truly increased risk
Amyotrophic lateral sclerosis · Confidence interval · Danish · Disease · Environmental health · Odds ratio · Population · Quartile · Alzheimer's disease research and treatments · Amyotrophic Lateral Sclerosis Research · Heavy Metal Exposure and Toxicity · Medicine · Internal Medicine
| Highly cited | No |
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