Hypertensive Disorders of Pregnancy and Pre-Pregnancy Hypertension with Subsequent Incident Venous Thromboembolic Events
Bibliographic Data
| ID | 15505437 |
|---|---|
| Authors | Angela M Malek (0000-0001-5691-5347, Medical University of South Carolina, corresponding author), Dulaney A Wilson (0000-0003-4726-7848, Medical University of South Carolina), Tanya N Turan (0000-0001-5399-8845, Medical University of South Carolina), Julio Mateus (0000-0001-6886-4807, Levine Cancer Institute), Daniel T Lackland (0000-0001-5733-6283, Medical University of South Carolina), Kelly J Hunt (0000-0001-8999-3587, Medical University of South Carolina) |
| Year | 2024 |
| Volume | 21 |
| Issue | 1 |
| Pages | 89-89 |
| Publication date | 2024-01-12 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph21010089 |
| PMID | 38248552 |
| OpenAlex | W4390796599 |
| Language | EN |
| References cited | 47 |
Hypertensive disorders of pregnancy (HDP) and pre-pregnancy hypertension contribute to maternal morbidity and mortality. We examined the association of HDP and pre-pregnancy hypertension with subsequent venous thromboembolic (VTE) events. The retrospective cohort study included 444,859 women with ≥1 live, singleton birth in South Carolina (2004-2016). Hospital and emergency department visit and death certificate data defined incident VTE, HDP, and pre-pregnancy hypertension. Birth certificate data also defined the exposures. Adjusted Cox proportional hazards methods modeled VTE events risk. Of the cohort, 2.6% of women had pre-pregnancy hypertension, 5.8% had HDP, 2.8% had both pre-pregnancy hypertension and HDP (both conditions), and 88.8% had neither condition. The risk of incident VTE events within one year of delivery was higher in women with HDP (hazard ratio [HR] = 1.62, 95% confidence interval [CI]: 1.15-2.29) and both conditions (HR = 2.32, 95% CI: 1.60-3.35) compared to those with neither condition as was the risk within five years for women with HDP (HR = 1.35, 95% CI: 1.13-1.60) and for women with both conditions (HR = 1.82, 95% CI: 1.50-2.20). One- and five-year risks did not differ in women with pre-pregnancy hypertension compared to women with neither condition. Compared to non-Hispanic White (NHW) women with neither condition, the incident VTE event risk was elevated within five years of delivery for NHW (HR = 1.29, 95% CI: 1.02-1.63; HR = 1.59, 95% CI: 1.16-2.17) and non-Hispanic Black (NHB; HR = 1.51, 95% CI: 1.16-2.96; HR = 2.08, 95% CI: 1.62-2.66) women with HDP and with both conditions, respectively, and for NHB women with pre-pregnancy hypertension (HR = 1.50, 95% CI: 1.09-2.07). VTE event risk was highest in women with HDP, and the event rates were higher in NHB women than in NHW women in the same exposure group
Obstetrics · Pregnancy · Thrombosis · Venous thromboembolism · Venous thrombosis · Blood Coagulation and Thrombosis Mechanisms · Maternal and fetal healthcare · Medicine · Pregnancy and preeclampsia studies · Internal Medicine
| Highly cited | No |
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