The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents
The Moderating Roles of the Monoamine Oxidase A (Maoa) Gene and the Catechol-O-Methyltransferase (Comt) Gene
Bibliographic Data
| ID | 15506311 |
|---|---|
| Authors | Yemiao Gao (0000-0001-8414-7736, Beijing Normal University), Yuke Xiong (Beijing Normal University), Xia Liu (0000-0003-1136-4742, Beijing Normal University, corresponding author), Hui Wang (0000-0001-5109-8691, Beijing Normal University) |
| Year | 2021 |
| Volume | 18 |
| Issue | 5 |
| Pages | 2598-2598 |
| Publication date | 2021-03-05 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18052598 |
| PMID | 33807669 |
| OpenAlex | W3134633623 |
| Language | EN |
| Citations received | 1 |
| References cited | 67 |
(1) Background: Numerous studies suggest strong associations between childhood maltreatment and nonsuicidal self-injury (NSSI); this is also true for the roles of dopaminergic genes in the etiology of some psychopathologies related to NSSI. Investigating the interactions of environments and genes is important in order to better understand the etiology of NSSI. (2) Methods: Within a sample of 269 Chinese male adolescents ( M age = 14.72, SD = 0.92), childhood maltreatment and NSSI were evaluated, and saliva samples were collected for MAOA T941G and COMT Val158Met polymorphism analyses. (3) Results: The results revealed no primary effects attributable to MAOA T941G and COMT Val158Met polymorphism on NSSI. However, there was a significant three-way interaction between MAOA, COMT, and child abuse (β = -0.34, p < 0.01) in adolescent NSSI. Except for carriers of the T allele of MAOA and the Met allele of COMT, all studied male adolescents displayed higher NSSI scores when exposed to a higher level of child abuse. A similar three-way interaction was not observed in the case of child neglect. (4) Conclusions: The results indicate that the MAOA gene and COMT gene play moderating roles in the association between child abuse and NSSI of male adolescents and suggest the polygenic underpinnings of NSSI
Allele · Biology · Catechol-O-methyl transferase · Child abuse · Gene · Injury prevention · Medical emergency · Monoamine oxidase · Monoamine oxidase A · Monoamine oxidase B · Neglect · Poison control · Psychiatry · Serotonin · Attention Deficit Hyperactivity Disorder · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Medicine · Psychology · Suicide and Self-Harm Studies · Genetics · Internal Medicine
Screening for Depressive Disorder in Children and Adolescents
Self-injurious thoughts and behaviors as risk factors for future suicide ideation, attempts, and death
Childhood maltreatment and non-suicidal self-injury
Solving the puzzle of deliberate self-harm
Role of Genotype in the Cycle of Violence in Maltreated Children
Major Depressive Disorder
Prevalence of Nonsuicidal Self‐Injury in Nonclinical Samples
Stress, sensitive periods and maturational events in adolescent depression
The Epidemiology and Phenomenology of Non-Suicidal Self-Injurious Behavior Among Adolescents
Why Do People Hurt Themselves?
The longitudinal course of non-suicidal self-injury and deliberate self-harm
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
Controlling the False Discovery Rate
Impulsivity in Non-Suicidal Self-Injurious Adolescents in China
The interactive effects of monoamine oxidase A (Maoa) gene and peer victimization on depressive symptoms in early adolescent boys
Association between negative life events and early adolescents’ depression
Cognitive, Neurobiological and Psychopathological Alterations Associated with Child Maltreatment
Child Maltreatment in Western China
Distress Intolerance Mediates the Relationship between Child Maltreatment and Nonsuicidal Self-Injury among Chinese Adolescents
The Catechol-O-Methyltransferase and Dopamine Transporter Genes Moderated the Impact of Peer Relationships on Adolescent Depressive Symptoms
A biosocial developmental model of borderline personality
Beyond diathesis stress
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |