Potential Toxic Effects of Exposure to Titanium Silicon Oxide Nanoparticles in Male Rats
Bibliographic Data
| ID | 15510077 |
|---|---|
| Authors | Shimaa Ghareeb (0000-0002-6222-7513, Ministry of Agriculture and Land Reclamation), Didair A Ragheb (Zagazig University), Didair Ragheb (Zagazig University), Aly El-Sheakh (Ministry of Agriculture and Land Reclamation), Mohamed-Bassem A Ashour (0000-0003-3518-2265, Zagazig University, corresponding author) |
| Year | 2022 |
| Volume | 19 |
| Issue | 4 |
| Pages | 2029-2029 |
| Publication date | 2022-02-11 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19042029 |
| PMID | 35206216 |
| OpenAlex | W4213078586 |
| Language | EN |
| References cited | 52 |
Recently, nano titanium silicon oxide (TiSiO 4 NPs) has been used in different fields and industries. Very few toxicological data exist for TiSiO 4 NPs. In the present study, the potential adverse effects of oral exposure to a single dose of TiSiO 4 NPs ≤ 50 nm (250 mg/kg b.w.) in adult male rats were investigated through the assessment of biomarkers for serum biochemical parameters, liver DNA damage, and histopathological examination and determination of Si and Ti in the exposed rat tissues. The results revealed that there were no significant changes in serum total protein, albumin, and triglycerides content, while total cholesterol level was significantly increased 7 days after exposure. TiSiO 4 NPs significantly increased superoxide dismutase (SOD), glutathione peroxidase (GPx), acetylcholine esterase (AChE), lactate dehydrogenase (LDH) activity, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels in the exposed rat serum, whereas alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity, urea level, immunoglobulins (IgG and IgM) concentrations, progesterone, and testosterone levels were significantly decreased. The liver comet assay indices were significantly increased after 7 days post-exposure. Moreover, histopathological changes and the accumulation of Si and Ti in liver, kidney, spleen, and lung tissues of treated rats were recorded
Albumin · Biology · Enzyme · Glutathione peroxidase · Hormone · Lactate dehydrogenase · Luteinizing hormone · Oxidative stress · Superoxide dismutase · Testosterone (patch · Aluminum toxicity and tolerance in plants and animals · Chemistry · Heavy Metal Exposure and Toxicity · Medicine · Nanoparticles: synthesis and applications · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
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