Impact of Chemotherapy-Induced Peripheral Neuropathy on Quality of Life in Patients with Advanced Lung Cancer Receiving Platinum-Based Chemotherapy
Bibliographic Data
| ID | 15510335 |
|---|---|
| Authors | Hsing-Wei Hung (Chang Gung University), Chien‐Ying Liu (0000-0002-8521-3456, Chang Gung University), Hsiu‐Fang Chen (0000-0001-7994-4589, Chang Gung University of Science and Technology), Chun-Chu Chang (0000-0003-1450-5344, Chang Gung University of Science and Technology), Shu‐Ching Chen (0000-0001-9209-390X, corresponding author), Shu-Ching Chen (0000-0002-7921-1964, Chang Gung University of Science and Technology, corresponding author) |
| Year | 2021 |
| Volume | 18 |
| Issue | 11 |
| Pages | 5677-5677 |
| Publication date | 2021-05-26 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18115677 |
| PMID | 34073174 |
| OpenAlex | W3131428337 |
| Language | EN |
| Citations received | 1 |
| References cited | 3 |
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of neurotoxic anticancer drugs that may affect quality of life (QoL). Purpose: The purposes of this study were to: assess the levels of CIPN, anxiety, depression, CIPN-related QoL, and general QoL; and identify the factors related to CIPN-related QoL and general QoL in patients with advanced lung cancer (LC) receiving platinum-based chemotherapy. This cross-sectional study examined patients with advanced LC who received platinum-based chemotherapy from the thoracic oncology inpatient wards of a medical center in northern Taiwan. Structured questionnaires were used to measure patients' CIPN (European Organization for Research and Treatment of Cancer quality of life questionnaire-chemotherapy-induced peripheral neuropathy 20), anxiety (Hospital Anxiety and Depression Scale Depression Scale [HADS]), depression (HADS), CIPN-related QoL (Functional Assessment of Cancer Therapy /Gynecologic Oncology Group-Neurotoxicity subscale [FACT/GOG-Ntx]), and general QoL (Functional Assessment of Cancer Therapy-General Input [FACT-G]). Of 93 patients with advanced LC, 53.8% reported CIPN-sensory impairment and 47.3% reported CIPN-motor impairment. The most common CIPN symptoms were difficulty getting or maintaining an erection (only for men > 65 years) and difficulty in climbing stairs or getting up out of a chair. Poor CIPN-related QoL (FACT/GOG-Ntx) was associated with more CIPN-sensory and more CIPN-motor impairment. Poor general QoL (FACT-G) was associated with a higher level of depression, a higher level of anxiety, and receipt of more chemotherapy cycles. More than half of LC patients report impairment related to CIPN, calling for holistic treatment to improve QoL
Biology · Cancer · Chemotherapy · Chemotherapy-induced peripheral neuropathy · Diabetes mellitus · Lung cancer · Peripheral · Peripheral neuropathy · Platinum · Quality of life (healthcare · Cancer Treatment and Pharmacology · Glioma Diagnosis and Treatment · Management of metastatic bone disease · Medicine · Endocrinology · Internal Medicine · Oncology
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |