Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy

Bibliographic Data

ID15511101
AuthorsMassimiliano Balbi (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Valter Donadon (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy, corresponding author), Michela Ghersetti (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Silvia Grazioli (0000-0002-7789-2815, Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Giovanni Della Valentina (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Rita Gardenal (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Maria Dal Mas (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Pietro Casarin (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Giorgio Zanette (Diabetes Clinic, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Cesare Miranda (0000-0002-9247-8372, Diabetes Clinic, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy), Paolo Cimarosti (Community Addictions Service, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)
Year2010
Volume7
Issue4
Pages1366-1378
Publication date2010-03-29
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph7041366
PMID20617035
PMCIDPMC2872357
OpenAlexW2084304207
LanguageEN
Citations received2
References cited36

Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection

Alcohol · Alcohol abuse · Alcohol consumption · Biology · Cirrhosis · Diabetes mellitus · Hepatitis C · Hepatocellular carcinoma · Liver cancer · Odds ratio · Psychiatry · Risk factor · Type 2 Diabetes Mellitus · Alcohol Consumption and Health Effects · Liver Disease Diagnosis and Treatment · Medicine · Metabolism, Diabetes, and Cancer · Endocrinology · Gastroenterology · Internal Medicine

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