Trends in Incidence and Mortality of Primary Liver Cancer in Lithuania 1998–2015

Bibliographic Data

ID15511190
AuthorsAudrius Dulskas (0000-0003-3692-8962, Vilnius University, corresponding author), Povilas Kavaliauskas (0000-0003-0237-9088, Vilnius University), Kęstutis Žagminas (0000-0002-5682-7125, Vilnius University), Ligita Jančorienė (0000-0001-6488-6312, Vilnius University), Giedrė Smailytė (0000-0001-8365-543X, Vilnius University)
Year2021
Volume18
Issue3
Pages1191-1191
Publication date2021-01-29
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18031191
PMID33572744
OpenAlexW3123902024
LanguageEN
References cited30

Background : Recently, reports have suggested that rates of liver cancer have increased during the last decades in developed countries; increasing hepatocellular carcinoma and cholangiocarcinoma rates were reported. The aim of this study was to examine time trends in incidence and mortality rates of liver cancer for the period of 1998-2015 in Lithuania by sex, age, and histology. Methods : We examined the incidence of liver cancer from 1998 to 2015 using data from the Lithuanian Cancer Registry. Age-standardized incidence rates were calculated by sex, age, and histology. Trends were analyzed using the Joinpoint Regression Program to estimate the annual percent change. Results : A total of 3086 primary liver cancer cases were diagnosed, and 2923 patients died from liver cancer. The total number of liver cancer cases changed from 132 in 1998 to 239 in 2015. Liver cancer incidence rates changed during the study period from 5.02/100,000 in 1998 to 10.54/100,000 in 2015 in men and from 2.43/100,000 in 1998 to 6.25/100,000 in 2015 in women. Annual percentage changes (APCs) in the age-standardized rates over this period were 4.5% for incidence and 3.6% for mortality. Hepatocellular cancer incidence rates were stable from 1998 to 2005 (APC -5.9, p = 0.1) and later increased by 6.7% per year ( p Conclusions : Primary liver cancer incidence and mortality increased in both sexes in Lithuania. The rise om incidence was observed in both sexes and main histology groups. The increasing incidence trend may be related to the prevalence of main risk factors (alcohol consumption, hepatitis B and C infections. and diabetes)

Cancer · Cancer registry · Hepatocellular carcinoma · Incidence (geometry · Liver cancer · Mortality rate · Demography · Hepatitis B Virus Studies · Hepatocellular Carcinoma Treatment and Prognosis · Liver Disease Diagnosis and Treatment · Medicine · Internal Medicine

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