Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients
Bibliographic Data
| ID | 15512540 |
|---|---|
| Authors | Joanna Kocot (Medical University of Lublin, corresponding author), Piotr Dziemidok (0000-0003-2539-0044, Instytut Medycyny Wsi im. Witolda Chodźki), Małgorzata Kiełczykowska (0000-0002-3637-2856, Medical University of Lublin), Jacek Kurzepa (0000-0002-7524-8831, Medical University of Lublin), Grzegorz Szczęśniak (Instytut Medycyny Wsi im. Witolda Chodźki), Irena Musik (0000-0002-5497-3081, Medical University of Lublin) |
| Year | 2017 |
| Volume | 15 |
| Issue | 1 |
| Pages | 19-19 |
| Publication date | 2017-12-23 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph15010019 |
| PMID | 29295491 |
| OpenAlex | W2778184530 |
| Language | EN |
| Citations received | 1 |
A growing interest in the role of vitamin D in metabolic diseases led us to study the relationships between 25-hydroxyvitamin D3 (25(OH)D3) and the profiles of selected adipokines in type 2 diabetic (T2DM) patients. The study comprised 92 type 2 diabetics divided into quartiles regarding 25(OH)D3 concentration. Each group was divided into male and female subgroups. All the studied patients had their anthropometric and biochemical parameters determined. Plasma 25-hydroxyvitamin D3 concentration was determined by HPLC, while the selected adipokines (leptin, adiponectin, resistin and visfatin) by ELISA methods. The ratio of leptin to adiponectin (L/A) was calculated for all the patients. In 85.3% of diabetics a full (<20 ng/mL) or moderate (20-30 ng/mL) vitamin D deficit was found. Irrespective of sex, plasma leptin concentration decreased across increasing quartiles of 25(OH)D3 level. In women, 25(OH)D3 was negatively correlated with BMI, leptin level as well as L/A ratio, and positively with adiponectin concentration. In men, 25(OH)D3 was positively correlated with HDL and negatively with systolic blood pressure (SBP), leptin level and L/A ratio. Considering all the patients, there ocurred a significant negative correlation between 25(OH)D3 and SBP, BMI, WHR, TG, leptin and L/A ratio and positive ones between 25(OH)D3 and both adiponectin and HDL. The results of the study support the existence of the relationship among vitamin D, obesity and leptin in type 2 diabetic patients
Adipokine · Adiponectin · Confidence interval · Diabetes mellitus · Insulin resistance · Leptin · Obesity · Quartile · Resistin · Type 2 diabetes · Vitamin · Vitamin D and neurology · Adipokines, Inflammation, and Metabolic Diseases · Chemistry · Medicine · Regulation of Appetite and Obesity · Vitamin D Research Studies · Endocrinology · Internal Medicine
| Citations per year | 0.2 |
|---|---|
| Citation span | 2021 - 2021 (1) |
| Highly cited | No |