In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids
Bibliographic Data
| ID | 15512622 |
|---|---|
| Authors | Aurélie Pelfrêne (0000-0001-5339-7361, Laboratoire de Mécanique et Génie Civil, corresponding author), Mark Cave (0000-0003-2752-7155, British Geological Survey), Joanna Wragg (0000-0003-0011-641X, British Geological Survey), Francis Douay (Laboratoire de Mécanique et Génie Civil) |
| Year | 2017 |
| Volume | 14 |
| Issue | 2 |
| Pages | 112-112 |
| Publication date | 2017-01-24 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph14020112 |
| PMID | 28125027 |
| OpenAlex | W2581625788 |
| Language | EN |
| Citations received | 1 |
| References cited | 74 |
An investigation for assessing pulmonary bioaccessibility of metals from reference materials is presented using simulated lung fluids. The objective of this paper was to contribute to an enhanced understanding of airborne particulate matter and its toxic potential following inhalation. A large set of metallic elements (Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, and Zn) was investigated using three lung fluids (phosphate-buffered saline, Gamble's solution and artificial lysosomal fluid) on three standard reference materials representing different types of particle sources. Composition of the leaching solution and four solid-to-liquid (S/L) ratios were tested. The results showed that bioaccessibility was speciation- (i.e., distribution) and element-dependent, with percentages varying from 0.04% for Pb to 86.0% for Cd. The higher extraction of metallic elements was obtained with the artificial lysosomal fluid, in which a relative stability of bioaccessibility was observed in a large range of S/L ratios from 1/1000 to 1/10,000. For further investigations, it is suggested that this method be used to assess lung bioaccessibility of metals from smelter-impacted dusts
Chromatography · Extraction (chemistry · Leaching (pedology · Metal · Metallurgy · Particulates · Soil water · Air Quality and Health Impacts · Chemistry · Environmental Science · Heavy metals in environment · Materials Science · Radioactivity and Radon Measurements · Environmental Chemistry · Soil Science
| Citations per year | 0.2 |
|---|---|
| Citation span | 2021 - 2021 (1) |
| Highly cited | No |