Midlife Urinary Phthalate Metabolite Concentrations and Prior Uterine Fibroid Diagnosis
Bibliographic Data
| ID | 15512674 |
|---|---|
| Authors | Diana C Pacyga (0000-0002-4158-2751, Michigan State University), Brad A Ryva (0000-0001-9698-9279, Michigan State University), Romana A Nowak (0000-0001-6578-5695, University of Illinois Urbana-Champaign), Serdar E Bulun (0000-0003-0850-8637, Northwestern University), Ping Yin (0000-0002-6818-1552, Northwestern University), Li Zhong (0000-0003-2895-2217, University of Illinois Urbana-Champaign), Zhong Li (0000-0003-1124-5778, Roy J. Carver Biotechnology Center, University of Illinois, Urbana-Champaign, IL 61801, USA), Jodi A Flaws (0000-0001-5579-9268, University of Illinois Urbana-Champaign), Rita S Strakovsky (0000-0002-3551-1615, Michigan State University, corresponding author) |
| Year | 2022 |
| Volume | 19 |
| Issue | 5 |
| Pages | 2741-2741 |
| Publication date | 2022-02-26 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19052741 |
| PMID | 35270433 |
| OpenAlex | W4214771173 |
| Language | EN |
| References cited | 49 |
Fibroid etiology is poorly understood but is likely hormonally mediated. Therefore, we evaluated associations between midlife phthalates (hormone-altering chemicals) and prior fibroid diagnosis, and considered differences by weight gain status. Women (ages: 45−54; n = 754) self-reported past fibroid diagnosis. We pooled 1−4 urines collected after fibroid diagnosis over the consecutive weeks to analyze nine phthalate metabolites and calculate relevant molar sums (e.g., di(2-ethylhexyl) phthalate, ΣDEHP; anti-androgenic phthalates, ΣAA; all metabolites, ΣPhthalates). Using Poisson regression, we evaluated associations between phthalate biomarkers and the risk of having fibroid diagnosis. We explored if associations differed by weight gain from age 18 to 45−54 or in women diagnosed with fibroids within 5 years of phthalate assessment. Our major finding was that women had a 13% (RR: 1.13; 95%CI: 1.02, 1.26) and 16% (RR: 1.16; 95% CI: 1.03, 1.31) greater risk of prior fibroid diagnosis for each two-fold increase in ΣDEHP or ΣAA, respectively. These associations were strongest in women who became overweight/obese from age 18 to 45−54 and in those diagnosed <5 years before phthalate assessment. Based on these results, prospective studies should corroborate our findings related to associations between phthalates and fibroids, and may consider evaluating the role that weight gain may play in these associations
Body mass index · Gynecology · Metabolite · Obstetrics · Overweight · Phthalate · Uterine fibroids · Chemistry · Effects and risks of endocrine disrupting chemicals · Medicine · Internal Medicine · Physiology
| Highly cited | No |
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