The Lesson Learned from the Covid-19 Pandemic
Can an Active Chemical Be Effective, Safe, Harmless-for-Humans and Low-Cost at a Time? Evidence on Aerosolized Hypochlorous Acid
Bibliographic Data
| ID | 15512730 |
|---|---|
| Authors | Mascia Benedusi (0000-0002-4656-8609, University of Ferrara), Elena Tamburini (0000-0001-9830-7649, University of Ferrara, corresponding author), Mariaconcetta Sicurella (0000-0003-3996-3667, University of Ferrara), Daniela Summa (0000-0002-1483-268X, University of Ferrara), Francesca Ferrara (0000-0002-3322-8015, University of Ferrara), Peggy Marconi (0000-0003-3488-0491, University of Ferrara), Franco Cervellati (0000-0002-0051-2597, University of Ferrara), Stefania Costa (0000-0002-7555-2681, University of Ferrara), Giuseppe Valacchi (0000-0002-8792-0947, University of Ferrara) |
| Year | 2022 |
| Volume | 19 |
| Issue | 20 |
| Pages | 13163-13163 |
| Publication date | 2022-10-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph192013163 |
| OpenAlex | W4306149583 |
| Language | EN |
| References cited | 51 |
The COVID-19 pandemic has underlined the importance of disinfectants as tools to prevent and fight against coronavirus spreading. An ideal disinfectant and sanitizer must be nontoxic to surface contact, noncorrosive, effective, and relatively inexpensive as it is hypochlorous acid (HOCl). The present work intended to evaluate, on different surfaces, the bactericidal and virucidal effectiveness of nebulized HOCl and test its safety usage in 2D and 3D skin and lung models. Our data showed that HOCl at the dose of 300 ppm did not affect cellular and tissue viability, not their morphology. The HOCl bactericidal properties varies with the surface analyzed: 69% for semi-porous, 96–99.9% for flat and porous. This discrepancy was not noticed for the virucidal properties. Overall, this study showed that nebulized HOCl can prevent virus and bacteria growth without affecting lung and skin tissues, making this compound a perfect candidate to sanitize indoor environments
2019-20 coronavirus outbreak · Aerosolization · Anesthesia · Betacoronavirus · Coronavirus disease 2019 (COVID-19 · Coronavirus Infections · Hypochlorous acid · Infectious disease (medical specialty · Medical emergency · Outbreak · Pandemic · Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 · Air Quality and Health Impacts · Chemistry · Climate Change and Health Impacts · Healthcare and Environmental Waste Management · Medicine · Internal Medicine · Virology
| Highly cited | No |
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