Dose–Response Analysis of the Tubular and Glomerular Effects of Chronic Exposure to Environmental Cadmium
Bibliographic Data
| ID | 15512919 |
|---|---|
| Authors | Soisungwan Satarug (Translational Research Institute, corresponding author), David A Vesey (0000-0002-2856-6650, Princess Alexandra Hospital), Glenda C Gobe (0000-0002-8732-7908, Translational Research Institute) |
| Year | 2022 |
| Volume | 19 |
| Issue | 17 |
| Pages | 10572-10572 |
| Publication date | 2022-08-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph191710572 |
| PMID | 36078287 |
| OpenAlex | W4293104272 |
| Language | EN |
| Citations received | 1 |
| References cited | 42 |
We retrospectively analyzed data on the excretion of cadmium (E Cd ), β 2 -microglobulin (E β2M ) and N-acetyl-β-D-glucosaminidase (E NAG ), which were recorded for 734 participants in a study conducted in low- and high-exposure areas of Thailand. Increased E β2M and E NAG were used to assess tubular integrity, while a reduction in the estimated glomerular filtration rate (eGFR) was a criterion for glomerular dysfunction. E Cd , E β2M and E NAG were normalized to creatinine clearance (C cr ) as E Cd /C cr , E β2M /C cr and E NAG /C cr to correct for interindividual variation in the number of surviving nephrons and to eliminate the variation in the excretion of creatinine (E cr ). For a comparison, these parameters were also normalized to E cr as E Cd /E cr , E β2M /E cr and E NAG /E cr . According to the covariance analysis, a Cd-dose-dependent reduction in eGFR was statistically significant only when E cd was normalized to C cr as E Cd /C cr ( F = 11.2, p 2 in those with the highest E Cd /C cr range ( p = 0.002). In addition, doubling of E Cd /C cr was associated with lower eGFR (β = -0.300, p NAG /C cr (β = 0.455, p β2M /C cr (β = 0.540, p Cd /E cr and eGFR ( F = 1.08, p = 0.165), while the risk of low eGFR was increased by 6.9-fold only among those with the highest E Cd /E cr range. Doubling of E Cd /E cr was associated with lower eGFR and higher E NAG /E cr and E β2M /E cr , with the β coefficients being smaller than in the C cr -normalized dataset. Thus, normalization of Cd excretion to C cr unravels the adverse effect of Cd on GFR and provides a more accurate evaluation of the severity of the tubulo-glomerular effect of Cd
Creatinine · Excretion · Renal function · Chemistry · Chronic Kidney Disease and Diabetes · Heavy Metal Exposure and Toxicity · Insurance, Mortality, Demography, Risk Management · Medicine · Endocrinology · Internal Medicine · Urology
Estimation of Average Concentration in the Presence of Nondetectable Values
Association of Blood Heavy Metal Levels and Renal Function in Korean Adults
Associations between Urinary Excretion of Cadmium and Renal Biomarkers in Nonsmoking Females
Low level exposure to cadmium increases the risk of chronic kidney disease
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |