The Association of Self-Reported Birthweight with Lung Function and Respiratory Diseases

Results from a Multi-Centre, Multi-Case Control Study in Italy

Bibliographic Data

ID15512928
AuthorsIlaria Tocco Tussardi (0000-0001-6651-2664, University of Verona), Ahmad Tfaily (0000-0003-0113-6156, University of Verona), Francesca Locatelli (0000-0001-9190-7190, University of Verona), Leonardo Antonicelli (0000-0002-7669-9116, Ospedali Riuniti di Ancona), Salvatore Battaglia (0000-0002-2867-917X, University of Palermo), Roberto Bono (0000-0002-2471-6594, Department of Public Health and Paediatrics, University of Torino, 10124 Torino, Italy), Angelo Guido Corsico (0000-0002-8716-4694, University of Pavia), Nicola Murgia (0000-0001-8180-1018, University of Perugia), Pietro Pirina (0000-0003-1457-8025, University of Sassari), Marcello Ferrari (0000-0001-9527-5952, University of Verona), Stefano Tardivo (0000-0002-9161-2189, University of Verona), Deborah Jarvis (0000-0002-1753-3896, Imperial College London), Deborah L Jarvis (National Heart and Lung Institute, Section of Genomic and Environmental Medicine, Imperial College London, London SW7 2BX, UK), Giuseppe Verlato (0000-0001-5262-8818, University of Verona, corresponding author)
Year2022
Volume19
Issue22
Pages15062-15062
Publication date2022-11-16
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph192215062
PMID36429783
OpenAlexW4309153982
LanguageEN
References cited51

Early life conditions are associated with lung function and the development of respiratory and non-respiratory illnesses. The relationship with birthweight (BW), however, is conflicting. We examined associations of self-reported BW with lung function and the development of respiratory and also non-respiratory diseases within the GEIRD (Gene-Environment Interaction in Respiratory Diseases) project, an Italian multi-centre, multi-case control study involving cases of COPD, asthma, allergic rhinitis and controls. Multinomial logistic regression was performed with case/control status as response variable; BW as main determinant; and adjusting for sex, age and smoking status. Of the 2287 participants reporting BW, 6.4% (n = 147) had low BW ( p = 0.006). Both men and women with low BW were shorter than those with normal BW (mean ± SD: 160.2 ± 5.5 vs. 162.6 ± 6.5 cm in women, p = 0.009; 172.4 ± 6.1 vs. 174.8 ± 7.2 cm in men, p p p = 0.001) and hypertension in adulthood (29.9% vs. 23.7%; p = 0.001); however, they had a lower risk of arrhythmia (2.7% vs. 5.8%; p = 0.027)

Asthma · Case-control study · COPD · Logistic regression · Lung · Respiratory disease · Respiratory system · Birth, Development, and Health · Child and Adolescent Health · Medicine · Neonatal Respiratory Health Research · Internal Medicine · Pediatrics

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