Identification of Risk Factors to Predict the Occurrences of Relapses in Individuals with Schizophrenia Spectrum Disorder in Iran

Bibliographic Data

ID15513567
AuthorsOmran Davarinejad (0000-0002-4267-7867, Kermanshah University of Medical Sciences), Tahereh Mohammadi Majd (0000-0003-2229-9077, Kermanshah University of Medical Sciences), Farzaneh Golmohammadi (Kermanshah University of Medical Sciences), Payam Mohammadi (0000-0002-9968-0418, Kermanshah University of Medical Sciences), Farnaz Radmehr (0000-0003-0804-4393, Kermanshah University of Medical Sciences), Mostafa Alikhani (0000-0001-6848-3027, Kermanshah University of Medical Sciences), Tayebeh Motaei (Kermanshah University of Medical Sciences), Mehdi Moradinazar (0000-0001-7033-6755, Kermanshah University of Medical Sciences), Annette Beatrix Brühl (0000-0003-4704-4986, University of Basel), Dena Sadeghi Bahmani (0000-0002-1301-5522, University of Basel), Serge Brand (0000-0003-2175-2765, University of Basel, corresponding author)
Year2021
Volume18
Issue2
Pages546-546
Publication date2021-01-11
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18020546
PMID33440817
OpenAlexW3120566551
LanguageEN
Citations received3
References cited50

Schizophrenia Spectrum Disorder (SSD) is a chronic psychiatric disorder with a modest treatment outcome. In addition, relapses are commonplace. Here, we sought to identify factors that predict relapse latency and frequency. To this end, we retrospectively analyzed data for individuals with SSD. Medical records of 401 individuals with SSD were analyzed (mean age: 25.51 years; 63.6% males) covering a five-year period. Univariate and multivariate Penalized Likelihood Models with Shared Log-Normal Frailty were used to determine the correlation between discharge time and relapse and to identify risk factors. A total of 683 relapses were observed in males, and 422 relapses in females. The Relapse Hazard Ratio (RHR) decreased with age (RHR = 0.99, CI: (0.98-0.998)) and with participants' adherence to pharmacological treatment (HR = 0.71, CI: 0.58-0.86). In contrast, RHR increased with a history of suicide attempts (HR = 1.32, CI: 1.09-1.60), and a gradual compared to a sudden onset of disease (HR = 1.45, CI: 1.02-2.05). Gender was not predictive. Data indicate that preventive and therapeutic interventions may be particularly important for individuals who are younger at disease onset, have a history of suicide attempts, have experienced a gradual onset of disease, and have difficulties adhering to medication

Age of onset · Confidence interval · Disease · Hazard ratio · Medical record · Multivariate analysis · Proportional hazards model · Psychiatry · Psychological intervention · Psychosis · Schizophrenia (object-oriented programming · Schizophrenia Spectrum · Bipolar Disorder and Treatment · Medicine · Schizophrenia research and treatment · Treatment of Major Depression · Internal Medicine

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