Vitamin D and Calcium Milk Fortification in Pregnant Women with Periodontitis

A Feasibility Trial

Bibliographic Data

ID15513992
AuthorsAmanda Rodrigues Amorim Adegboye (0000-0003-2780-0350, University of Greenwich, corresponding author), Danilo Dias Santana (0000-0002-9769-7435, Universidade Federal do Rio de Janeiro), Paula Guedes Cocate (0000-0003-1208-6481, Universidade Federal do Rio de Janeiro), Camila Benaim (0000-0001-8822-062X, Universidade Federal do Rio de Janeiro), Pedro Paulo Teixeira dos Santos (0000-0002-2645-0187, Universidade Federal do Rio de Janeiro), Berit L Heitmann (0000-0002-6809-4504, Frederiksberg Hospital), Maria Cláudia Da Veiga Soares Carvalho (0000-0001-8286-5689, Universidade Federal do Rio de Janeiro), Michael Maia Schlüssel (0000-0002-1711-9310, Nuffield Orthopaedic Centre), Maria Beatriz Trindade De Castro (0000-0001-6618-4007, Universidade Federal do Rio de Janeiro), Gilberto Kac (0000-0001-8603-9077, Universidade Federal do Rio de Janeiro)
Year2020
Volume17
Issue21
Pages8023-8023
Publication date2020-10-30
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17218023
PMID33143369
OpenAlexW3094908576
LanguageEN
Citations received1
References cited26

This study aims to assess the acceptability, adherence, and retention of a feasibility trial on milk fortification with calcium and vitamin D (Ca+VitD) and periodontal therapy (PT) among low income Brazilian pregnant women with periodontitis (IMPROVE trial). This 2 × 2 factorial feasibility trial used a mixed-methods evaluation. In total, 69 pregnant women were randomly allocated to four groups: 1. fortified sachet with Ca+VitD and milk plus early PT (throughout gestation); 2. placebo and milk plus early PT; 3. fortified sachet with Ca+VitD and milk plus late PT after childbirth; 4. placebo and milk plus late PT. Data were collected via questionnaires, field notes, participant flow logs, treatment diary, and focal group discussions. Quantitative and qualitative data were analysed using appropriate descriptive statistics and content analysis, respectively. Eligibility rate (12%) was below the target of 15%, but participation (76.1%) and recruitment rate (2 women/week) exceeded the targets. Retention rate (78.6%) was slightly below the target (80%). Adherence to the PT was significantly higher in the early treatment groups (98.8%) compared to the late treatment groups (29%). All women accepted the random allocation, and baseline groups were balanced. There was no report of adverse events. This multi-component intervention is acceptable, well-tolerated, and feasible among low-risk pregnant women in Brazil

Biology · Calcium · Environmental health · Fortification · Obstetrics · Periodontitis · Pregnancy · Vitamin · Vitamin D and neurology · Chemistry · Dental Health and Care Utilization · Medicine · Oral microbiology and periodontitis research · Vitamin D Research Studies · Food Science · Internal Medicine · Physiology

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