Particulate Matter Exposure and Allergic Rhinitis

The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome

Bibliographic Data

ID15514038
AuthorsJacopo Mariani (0000-0003-0584-7481, University of Milan), Simona Iodice (0000-0001-5594-8761, University of Milan), Laura Cantone (0000-0003-3660-129X, University of Milan), Giulia Solazzo (0000-0002-5370-7507, University of Milan), Paolo Marraccini (0000-0001-5911-1360, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Emanuele Conforti (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Pallav A Bulsara (GlaxoSmithKline (United States)), Maria Stella Lombardi (0000-0002-4105-7228, GlaxoSmithKline (Switzerland)), Robert P Howlin (GlaxoSmithKline (United Kingdom)), Valentina Bollati (0000-0002-0370-9598, University of Milan), Luca Ferrari (0000-0002-4847-6337, University of Milan, corresponding author)
Year2021
Volume18
Issue20
Pages10689-10689
Publication date2021-10-12
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph182010689
PMID34682436
OpenAlexW3206920575
LanguageEN
Citations received1
References cited70

Particulate matter (PM) exposure is linked to the worsening of respiratory conditions, including allergic rhinitis (AR), as it can trigger nasal and systemic inflammation. To unveil the underlying molecular mechanisms, we investigated the effects of PM exposure on the release of plasmatic extracellular vesicles (EV) and on the complex cross-talk between the host and the nasal microbiome. To this aim, we evaluated the effects of PM 10 and PM 2.5 exposures on both the bacteria-derived-EV portion (bEV) and the host-derived EVs (hEV), as well as on bacterial nasal microbiome (bNM) features in 26 AR patients and 24 matched healthy subjects (HS). In addition, we assessed the role exerted by the bNM as a modifier of PM effects on the complex EV signaling network in the paradigmatic context of AR. We observed that PM exposure differently affected EV release and bNM composition in HS compared to AR, thus potentially contributing to the molecular mechanisms underlying AR. The obtained results represent the first step towards the understanding of the complex signaling network linking external stimuli, bNM composition, and the immune risponse

Bioinformatics · Biology · Context (archaeology · Dysbiosis · Extracellular vesicles · Immune system · Inflammation · Microbiome · Allergic Rhinitis and Sensitization · Asthma and respiratory diseases · Chemistry · Extracellular vesicles in disease · Cell Biology · Immunology · Microbiology

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