Investigating Potential Dose–Response Relationships between Vitamin D Status and Cognitive Performance
A Cross-Sectional Analysis in Middle- to Older-Aged Adults in the Busselton Healthy Ageing Study
Bibliographic Data
| ID | 15514083 |
|---|---|
| Authors | Janis D Harse (0000-0002-6212-3271, The University of Western Australia, corresponding author), Kun Zhu (0000-0002-8723-7574, Sir Charles Gairdner Hospital), Romola S Bucks (0000-0002-4207-4724, The University of Western Australia), Michael Hunter (0000-0002-0307-9127, The University of Western Australia), Ee Mun Lim (0000-0001-5879-5553, Queen Elizabeth II Medical Centre), Brian R Cooke (0000-0002-2232-1425, Fiona Stanley Hospital), John P Walsh (0000-0001-8568-9289, The University of Western Australia), Kevin Murray (0000-0002-8856-6046, The University of Western Australia) |
| Year | 2021 |
| Volume | 19 |
| Issue | 1 |
| Pages | 450-450 |
| Publication date | 2021-12-31 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph19010450 |
| PMID | 35010710 |
| OpenAlex | W4206314293 |
| Language | EN |
| Citations received | 1 |
| References cited | 50 |
Low vitamin D status has been linked to adverse cognitive outcomes in older adults. However, relationships at higher levels remain uncertain. We aimed to clarify patterns of association between vitamin D status and cognitive performance, using flexible regression methods, in 4872 middle- to older-aged adults (2678 females) from the Busselton Healthy Ageing Study. Cross-sectional associations of serum levels of 25-hydroxyvitamin D (25OHD) and performance in cognitive domains were modelled using linear regression and restricted cubic splines, controlling for demographic, lifestyle, and health factors. Mean ± SD serum 25OHD levels were 78 ± 24 nM/L for women and 85 ± 25 nM/L for men. Increasing levels in women were associated with better global cognition (linear trend, p = 0.023) and attention accuracy (continuity of attention), with improvement in the latter plateauing around levels of 80 nM/L (nonlinear trend, p = 0.035). In men, increasing levels of serum 25OHD were associated with better attention accuracy (linear trend, p = 0.022), but poorer semantic verbal fluency (linear trend, p = 0.025) and global cognition (nonlinear trend, p = 0.015). We identified patterns of association between serum 25OHD levels and cognitive performance that may reflect early dose-response relationships, particularly in women. Longitudinal analyses extending through to older ages may help to clarify the nature, strength, and temporality of these relationships
Ageing · Cognition · Cognitive decline · Cross-sectional study · Dementia · Disease · Effects of sleep deprivation on cognitive performance · Fluency · Healthy ageing · Healthy aging · Linear regression · Neuropsychology · Pathology · Psychiatry · Verbal fluency test · Vitamin D and neurology · Clinical Psychology · Demography · Medicine · Nutritional Studies and Diet · Psychology · Sodium Intake and Health · Vitamin D Research Studies · Gerontology · Internal Medicine
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| Unique citing works | 1 |
|---|---|
| Citations per year | 0.5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |