Vernonia amygdalina
Anticancer Activity, Authentication, and Adulteration Detection
Bibliographic Data
| ID | 15514337 |
|---|---|
| Authors | Lauren K Gresham (0000-0003-0688-0558, Jackson State University), Lecia J Gresham (The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies; College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA), Jetaime Ross (Jackson State University), Ernest B Izevbigie (Jackson State University, corresponding author) |
| Year | 2008 |
| Volume | 5 |
| Issue | 5 |
| Pages | 342-348 |
| Publication date | 2008-12-28 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph5050342 |
| PMID | 19151428 |
| OpenAlex | W2056994111 |
| Language | EN |
| Citations received | 2 |
| References cited | 23 |
Evidence suggests that most chemotherapeutic agents are less effective as treatment in patients with estrogen receptor-negative (ER-) breast carcinomas compared to those with estrogen receptor-positive (ER+) breast carcinomas. Moreover, African American Women (AAW) is disproportionately diagnosed with ER- breast cancer compared to their white counterparts. Novel therapies effective against ER- breast carcinomas are urgently needed to ameliorate the health disparity. Previous reports show that low concentrations (microgram/ml) of water-soluble leaf extracts of a Nigerian edible plant, V. amygdalina (VA), potently retards the proliferative activities of ER+ human breast cancerous cells (MCF-7) in vitro in a concentration-dependent fashion. However, the anti-proliferative activities of VA in either ductal or ER- carcinoma cells have not been characterized. The exposure of BT-549 to increasing concentrations of VA (10, 100, and 1000 microg/mL) inhibited cell growth by approximately 14 % (P<0.05), 22 % (p<0.05), and 50 % (p<0.005) respectively. The cell count studies were corroborated by DNA synthesis studies. Treatments of BT-549 with 10, 100, and 1000 microg/mL VA inhibited DNA synthesis in a concentration dependent fashion by 22 %, 76 % (P<0.05), and 86 % (p<0.01) respectively. BT-549 cells were insensitive to 10 and 100 nM paclitaxel (TAX) treatments. Isolation of DNA from dried VA leaves yielded approximately 12.2 and 1 kbp genomic DNA that were Eco RI-insensitive but Hind III and Bam HI-sensitive. These pieces of information may be used to enhance the safety of medicinal botanical VA through authentication, and adulteration detection
Breast cancer · Cancer · Cell growth · Estrogen · Estrogen receptor · In vitro · Microgram · Receptor · Traditional medicine · Vernonia amygdalina · Cassava research and cyanide · Chemistry · Drug-Induced Hepatotoxicity and Protection · Medicine · Natural Antidiabetic Agents Studies · Biochemistry · Cancer Research · Internal Medicine · Oncology
In vitro Amoebicidal Activity of some Medicinal Plants of the Bamun Region ( Cameroon)
Aqueous Vernomia amygdalina Extracts Alter MCF-7 Cell Membrane Permeability and Efflux
In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo
Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina
Ethnomedicinal and bioactive properties of plants ingested by wild chimpanzees in Uganda
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,15 |
| Citation span | 2013 - 2019 (7) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |