Differences in Treatment Outcomes and Prognosis between Elderly and Younger Patients Receiving Definitive Radiotherapy for Cervical Cancer

Bibliographic Data

ID15514567
AuthorsPei-Yu Hou (0000-0001-9073-6414, Far Eastern Memorial Hospital), Chen-Hsi Hsieh (0000-0003-0279-4695, National Yang Ming Chiao Tung University), Ming‐Chow Wei (Far Eastern Memorial Hospital), MingChow Wei (Departments of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan), Sheng‐Mou Hsiao (0000-0002-4381-9564, Far Eastern Memorial Hospital), Pei‐Wei Shueng (0000-0003-2051-364X, National Yang Ming Chiao Tung University, corresponding author), PeiWei Shueng (Department of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan)
Year2020
Volume17
Issue12
Pages4510-4510
Publication date2020-06-23
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17124510
PMID32585933
OpenAlexW3035833100
LanguageEN
References cited25

The aim was to compare the clinical outcomes and prognostic factors of cervical cancer between elderly and younger women, and to explore which treatment strategy is more appropriate for elderly patients. We retrospectively reviewed patients with cervical cancer receiving definitive radiotherapy (RT) between 2007 and 2016, and divided them into two age groups: age < 70 vs. age ≥ 70. The clinical outcomes were compared between the two age groups. The median follow-up was 32.2 months. A total of 123 patients were eligible, 83 patients in group 1 (age < 70), and 40 patients in group 2 (age ≥ 70). Patients in group 2 received less intracavitary brachytherapy (ICRT) application, less total RT dose, and less concurrent chemoradiotherapy (CCRT), and tended to have more limited external beam radiotherapy (EBRT) volume. The treatment outcomes between the age groups revealed significant differences in 5-year overall survival (OS), but no differences in 5-year cancer-specific survival (CSS), 66.2% vs. 64.5%, and other loco-regional control. In multivariate analyses for all patients, the performance status, pathology with squamous cell carcinoma (SCC), International Federation of Gynecology and Obstetrics (FIGO) stage, and ICRT application were prognostic factors of CSS. The elderly patients with cervical cancer had comparable CSS and loco-regional control rates, despite receiving less comprehensive treatment. Conservative treatment strategies with RT alone could be appropriate for patients aged ≥ 70 y/o, especially for those with favorable stages or histopathology

Brachytherapy · Cancer · Cervical cancer · Chemoradiotherapy · External beam radiotherapy · Multivariate analysis · Radiation therapy · Stage (stratigraphy · Cervical Cancer and HPV Research · Colorectal and Anal Carcinomas · Endometrial and Cervical Cancer Treatments · Medicine · Internal Medicine · Surgery

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