Deep Venous Thrombosis and Risk of Consequent Sepsis Event

A Retrospective Nationwide Population-Based Cohort Study

Bibliographic Data

ID15515178
AuthorsYing‐Tung Yeh (0000-0002-2803-5796, Chung Shan Medical University Hospital), Ying-Tung Yeh (Chung Shan Medical University), Sheng-En Tsai (0000-0003-4191-4944, Changhua Christian Hospital), Ying-Cheng Chen (0000-0002-3344-6266, Chung Shan Medical University Hospital), Shun‐Fa Yang (0000-0002-0365-7927, Chang Gung University), Han‐Wei Yeh (0000-0002-3216-6369, Chang Gung University), Bo-Yuan Wang (0000-0003-3135-0655, Chung Shan Medical University Hospital), Liang‐Tsai Yeh (0000-0002-3485-6937, Taichung Veterans General Hospital), Yu-Hsun Wang (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan), Nai-Chen Shih (0009-0009-2436-1023, Taichung Veterans General Hospital), Yu‐Hsun Wang (0000-0002-4937-6119, Chung Shan Medical University Hospital), Yin-Yang Chen (Chung Shan Medical University), Yin‐Yang Chen (0000-0002-6158-4025, Chung Shan Medical University Hospital), Chao‐Bin Yeh (0000-0002-3978-5576, Chung Shan Medical University Hospital, corresponding author)
Year2021
Volume18
Issue15
Pages7879-7879
Publication date2021-07-25
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph18157879
PMID34360172
OpenAlexW3184345260
LanguageEN
Citations received1
References cited45

Deep vein thrombosis causes several acute and chronic vessel complications and puts patients at risk of subsequent sepsis development. This unique study aimed to estimate the risk of sepsis development in DVT patients compared with non-DVT patients. This population-based cohort study used records of a longitudinal health insurance database containing two million patients defined in Taiwan's National Health Insurance Research Database (NHIRD). Our study included patients aged over 20 years with a new diagnosis of DVT with at least two outpatient department visits or an admission between 2001 and 2014. Patients with a diagnosis of sepsis before the index date were excluded. Propensity score matching (PSM) was used to homogenize the baseline characteristics between the two groups. To define the independent risk of the DVT group, a multivariate Cox proportional hazard model was used to estimate the hazard ratios. After PSM, the DVT group ( n = 5753) exhibited a higher risk of sepsis (adjusted hazard ratio, aHR, 1.74; 95% CI, 1.59-1.90) compared with non-DVT group ( n = 5753). Patients with an increased risk of sepsis were associated with being elderly aged, male, having diabetes, chronic kidney disease, chronic obstructive pulmonary disease, stroke, malignancy, and use of antibiotics. In conclusion, this population-based cohort study demonstrated an increased risk of sepsis in DVT patients compared with non-DVT patients. Thus, early prevention and adequate treatment of DVT is necessary in clinical practice

Cohort · Cohort study · Confidence interval · Deep vein · Environmental health · Hazard ratio · Intensive care medicine · Population · Propensity score matching · Proportional hazards model · Retrospective cohort study · Sepsis · Thrombosis · Central Venous Catheters and Hemodialysis · Diagnosis and Treatment of Venous Diseases · Medicine · Venous Thromboembolism Diagnosis and Management · Internal Medicine

Tools

Open DOIOpen Access