Early Left Ventricular Diastolic Dysfunction, Reduced Baroreflex Sensitivity, and Cardiac Autonomic Imbalance in Anabolic–Androgenic Steroid Users
Bibliographic Data
| ID | 15515948 |
|---|---|
| Authors | Evangelia Kouidi (0000-0002-5023-2542, Aristotle University of Thessaloniki), Αντωνία Καλτσάτου (0000-0003-2610-4900, Aristotle University of Thessaloniki), Maria Anifanti (0000-0003-0540-3581, Aristotle University of Thessaloniki), Maria Apostolos Anifanti (Aristotle University of Thessaloniki), Asterios Deligiannis (0000-0001-7765-1897, Aristotle University of Thessaloniki, corresponding author), Asterios Pantazis Deligiannis (Aristotle University of Thessaloniki) |
| Year | 2021 |
| Volume | 18 |
| Issue | 13 |
| Pages | 6974-6974 |
| Publication date | 2021-06-29 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18136974 |
| PMID | 34209901 |
| OpenAlex | W3175821277 |
| Language | EN |
| Citations received | 1 |
| References cited | 51 |
The effects of androgen anabolic steroids (AAS) use on athletes' cardiac autonomic activity in terms of baroreflex sensitivity (BRS), and heart rate variability (HRV) have not yet been adequately studied. Furthermore, there is no information to describe the possible relationship between the structural and functional cardiac remodeling and the cardiac autonomic nervous system changes caused by AAS abuse. Thus, we aimed to study the effects of long-term AAS abuse on cardiac autonomic efficacy and cardiac adaptations in strength-trained athletes. In total, 80 strength-trained athletes (weightlifters and bodybuilders) participated in the study. Notably, 40 of them using AAS according to their state formed group A, 40 nonuser strength-trained athletes comprised group B, and 40 healthy nonathletes (group C) were used as controls. All subjects underwent a head-up tilt test using the 30 min protocol to evaluate the baroreflex sensitivity and short HRV modulation. Furthermore, all athletes undertook standard echocardiography, a cardiac tissue Doppler imaging (TDI) study, and a maximal spiroergometric test on a treadmill to estimate their maximum oxygen consumption (VO 2 max). The tilt test results showed that group A presented a significantly lower BRS and baroreflex effectiveness index than group B by 13.8% and 10.7%, respectively ( p p p p p p 2 max by 15.1% ( p 2 max and LVMI in AAS users. The results of the present study indicated that long-term AAS use in strength-trained athletes led to altered cardiovascular autonomic modulations, which were associated with indices of early LV diastolic dysfunction
Autonomic nervous system · Baroreflex · Blood pressure · Cardiology · Diastole · Ejection fraction · Heart failure · Heart rate · Heart rate variability · Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control · Hormonal and reproductive studies · Medicine · Internal Medicine
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |