Long-Term Outcome of Repetitive Transcranial Magnetic Stimulation in a Large Cohort of Patients With Cocaine-Use Disorder
An Observational Study
Bibliographic Data
| ID | 15516124 |
|---|---|
| Authors | Graziella Madeo (0000-0001-7557-471X, PENTA Foundation), Alberto Terraneo (PENTA Foundation), Stefano Cardullo (0000-0002-6245-8741, PENTA Foundation), Luis J Gómez Pérez (0009-0008-1039-0037, PENTA Foundation), Nicola Cellini (0000-0003-0306-4408, University of Padua), Michela Sarlo (0000-0001-6652-7604, University of Padua), Antonello Bonci (0000-0003-0410-5507, Global Institutes on Addictions), Luigi Gallimberti (0000-0002-5724-7704, PENTA Foundation, corresponding author) |
| Year | 2020 |
| Volume | 11 |
| Pages | 158-158 |
| Publication date | 2020-02-28 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.00158 |
| PMID | 32180745 |
| OpenAlex | W3008578471 |
| Language | EN |
| Citations received | 6 |
| References cited | 2 |
Background: Cocaine is a psychostimulant drug used as performance enhancer throughout history. The prolonged use of cocaine is associated with addiction and a broad range of cognitive deficits. Currently, there are no medications proven to be effective for cocaine-use disorder (CocUD). Previous preliminary clinical work suggests some benefit from repetitive transcranial magnetic stimulation (rTMS) stimulating the prefrontal cortex (PFC), involved in inhibitory cognitive control, decision-making and attention. All published studies to date have been limited by small sample sizes and short follow-up times. Methods: This is a retrospective observational study of 284 outpatients (of whom 268 were men) meeting DSM-5 criteria for CocUD. At treatment entry, most were using cocaine every day or several times per week. All patients underwent 3 months of rTMS and were followed for up to 2 years, 8 months. Self-report, reports by family or significant others and regular urine screens were used to assess drug use. Results: Median time to the first lapse (resumption of cocaine use) since the beginning of treatment was 91 days. For most patients, TMS was re-administered weekly, then monthly, throughout follow-up. The decrease in frequency of rTMS sessions was not accompanied by an increase in lapses to cocaine use. Mean frequency of cocaine use was Conclusions: This is the first follow-up study to show that rTMS treatment is accompanied by long-lasting reductions in cocaine use in a large cohort
Addiction · Adverse effect · Anesthesia · Cocaine dependence · Cocaine use · Observational study · Psychiatry · Stimulation · Transcranial magnetic stimulation · Attention Deficit Hyperactivity Disorder · Medicine · Neural and Behavioral Psychology Studies · Psychology · Transcranial Magnetic Stimulation Studies · Internal Medicine
The role of repetitive transcranial magnetic stimulation (rTMS) in the treatment of behavioral addictions
A Retrospective Comparative Study in Patients With Cocaine Use Disorder Comorbid With Attention Deficit Hyperactivity Disorder Undergoing an rTMS Protocol Treatment
Transcranial magnetic stimulation in cocaine use disorder and the risk of seizure
RTMS investigation of resistant Obsessive-Compulsive Related Disorders
Role of maintenance treatment on long-term efficacy of bilateral iTBS of the prefrontal cortex in treatment-seeking cocaine addicts
High-frequency repetitive transcranial magnetic stimulation is associated with sustained improvement in cannabis use disorder
| Unique citing works | 6 |
|---|---|
| Citations per year | 1,2 |
| Citation span | 2021 - 2026 (6) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 6 |