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Transdiagnostic association between subjective insomnia and depressive symptoms in major psychiatric disorders

Bibliographic Data

ID15516151
AuthorsSuguru Nakajima (0009-0000-6917-4058, Nihon University), Yoshiyuki Kaneko (0000-0002-1588-7957, Nihon University, corresponding author), Nobukuni Fujii (Nihon University), Jun Kizuki (National Center of Neurology and Psychiatry), Kaori Saitoh (0000-0001-6751-9518, Nihon University), Kentaro Nagao (0000-0001-6497-2835, National Institute of Mental Health), Aoi Kawamura (0000-0002-7320-2848, National Center of Neurology and Psychiatry), Takuya Yoshiike (0000-0002-6071-8167, National Center of Neurology and Psychiatry), Hiroshi Kadotani (0000-0001-7474-3315, Shiga University of Medical Science), Naoto Yamada (0009-0002-2985-2410, Nagoya Memorial Hospital), Makoto Uchiyama (0000-0002-0199-2318, Nihon University), Kenichi Kuriyama (0000-0002-0254-4357, National Institute of Mental Health), Masahiro Suzuki (0000-0002-7925-2141, Nihon University, corresponding author)
Year2023
Volume14
Pages1114945-1114945
Publication date2023-04-24
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2023.1114945
PMID37168089
OpenAlexW4366832577
LanguageEN
Citations received2
References cited47

In psychiatric disorders, comorbid depressive symptoms are associated with clinically important issues such as reduced quality of life, a poor prognosis, and increased suicide risk. Previous studies have found a close relationship between insomnia and depressive symptoms in major depressive disorder (MDD), and that actively improving insomnia heightens the improvement of depressive symptoms. This study aimed to investigate whether the association between insomnia and depressive symptoms is also found in other psychiatric disorders besides MDD. The subjects were 144 patients with MDD ( n = 71), schizophrenia ( n = 25), bipolar disorder ( n = 22), or anxiety disorders ( n = 26). Sleep status was assessed subjectively and objectively using the Athens Insomnia Scale (AIS) and sleep electroencephalography (EEG), respectively. Sleep EEG was performed using a portable EEG device. Depressive symptoms were assessed using the Beck Depression Inventory. Subjective insomnia, as defined by the AIS, was associated with depressive symptoms in all disorders. Moreover, in schizophrenia, a relation between depressive symptoms and insomnia was also found by objective sleep assessment methods using sleep EEG. Our findings suggest that the association between subjective insomnia and depressive symptoms is a transdiagnostic feature in major psychiatric disorders. Further studies are needed to clarify whether therapeutic interventions for comorbid insomnia can improve depressive symptoms in major psychiatric disorders, similar to MDD

Anxiety · Association (psychology · Depression (economics · Depressive symptoms · Insomnia · Major depressive disorder · Mood · Psychiatry · Psychotherapist · Clinical Psychology · Medicine · Psychology · Sleep and related disorders · Sleep and Wakefulness Research · Tryptophan and brain disorders

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Unique citing works2
Citations per year2
Citation span2025 - 2025 (1)
Citation velocityrecent
Highly citedNo
Citation typesNeutral: 2

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