The Role of Acupuncture in Hormonal Shock-Induced Cognitive-Related Symptoms in Perimenopausal Depression

A Randomized Clinical Controlled Trial

Bibliographic Data

ID15516203
AuthorsJun-He Zhou (Guangzhou University of Chinese Medicine), Delong Zhang (0000-0002-0555-9642, South China Normal University), De-Long Zhang, Baile Ning (0000-0002-0354-5570, Guangzhou University of Chinese Medicine), Bai-Le Ning, Xiaojuan Xue (0000-0002-1622-1161, Ministry of Education), Xiao-Juan Xue, Lin Zhao (0000-0003-0245-8413, Guangzhou University of Chinese Medicine), Qian Wu (0000-0001-5828-6468, Guangzhou University of Chinese Medicine), Luda Yan (0009-0002-2669-8702, Guangzhou University of Chinese Medicine), Lu-Da Yan, Ming Liu (0000-0003-3177-4001, Ministry of Education), Wenbin Fu (0000-0002-6117-5547, Guangzhou University of Chinese Medicine, corresponding author), Wen-Bin Fu
Year2022
Volume12
Pages772523-772523
Publication date2022-01-13
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.772523
PMID35095593
OpenAlexW4206830804
LanguageEN
Citations received1
References cited40

Introduction: Perimenopausal depression is predominantly caused by hormone shock, but the underlying physical and psychological factors are still unclear. Objectives: To explore the constituent components of perimenopausal depression by dynamically depicting its influencing factors and interactive pathways from the perspective of embodied cognition. Methods: This is a randomized clinical controlled trial. In this study, electroacupuncture was compared with escitalopram. A total of 242 participants with mild to moderate perimenopausal depression were enrolled from 6 hospitals in China. Each participant had a 12-week intervention and a 12-week follow-up period. The primary outcome of this study is the Hamilton Depression Rating Scale (HAMD-17), and the secondary outcome is the menopause-specific quality of life scale (MENQOL), serum Follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estrogen (E 2 ) levels. Results: The structural equation model suggested that hormone levels were not directly associated with HAMD-17 ( P = 0.852), while MENQOL was statistically correlated with HAMD-17 as an intermediary variable ( P P Conclusions: Hormonal shock may affect clinical symptoms and poor quality of life to induce cognitive impairment leading perimenopausal depression, and this impact on cognition is embodied. Electroacupuncture has positive effect on perimenopausal depression and quality of life

Acupuncture · Alternative medicine · Cognition · Depression (economics · Hormone · Physical medicine and rehabilitation · Physical therapy · Psychiatry · Randomized controlled trial · Clinical Psychology · Medicine · Menopause: Health Impacts and Treatments · Menstrual Health and Disorders · Psychology · Stress Responses and Cortisol · Internal Medicine

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