Prescription of Anticholinergic Drugs in Patients With Schizophrenia

Analysis of Antipsychotic Prescription Patterns and Hospital Characteristics

Bibliographic Data

ID15516355
AuthorsHikaru Hori (0000-0001-8179-3054, Fukuoka University, corresponding author), Norio Yasui‐Furukori (0000-0002-4414-3770, Dokkyo Medical University), Norio Yasui-Furukori, Naomi Hasegawa (0000-0002-3834-4859, National Center of Neurology and Psychiatry), Jun‐ichi Iga (0000-0003-4409-3096, Ehime University), Shinichiro Ochi (0000-0003-2263-3477, Ehime University), Kayo Ichihashi (0000-0003-0389-2617, University of Tokyo Hospital), Ryuji Furihata (0000-0002-0809-2697, Kyoto University), Yoshitaka Kyo (Kitasato University), Yoshikazu Takaesu (0000-0002-9169-3249, University of the Ryukyus), Takashi Tsuboi (0000-0002-8253-8888, Kyorin University), Fumitoshi Kodaka (0000-0002-9296-5736, Jikei University School of Medicine), Toshiaki Onitsuka (0000-0001-6583-6405, Kyushu University), Tsuyoshi Okada (0000-0002-2240-5290, Jichi Medical University), Atsunobu Murata (National Institute of Mental Health), Hiroko Kashiwagi (0000-0003-4029-7868, National Center of Neurology and Psychiatry), Hitoshi Iida (0000-0002-2180-9998, Fukuoka University), Naoki Hashimoto (0000-0001-8311-7148, Hokkaido University), Kazutaka Ohi (0000-0001-9577-9640, Gifu University), Hisashi Yamada (0000-0002-0933-2330, National Center of Neurology and Psychiatry), Kazuyoshi Ogasawara (0000-0003-2911-0708, Nagoya University Hospital), Yuka Yasuda (0000-0002-2746-1590, National Institute of Mental Health), Hiroyuki Muraoka (0000-0003-1633-9079, Tokyo Women's Medical University), Masahide Usami (0000-0002-1145-9971, National Center for Global Health and Medicine), Shusuke Numata (0009-0009-0697-8871, Tokushima University), Masahiro Takeshima (0000-0003-0614-7524, Akita University), Hirotaka Yamagata (0000-0002-5783-7237, Yamaguchi University), Tatsuya Nagasawa (0000-0002-8070-9102, Kanazawa Medical University), Hiromi Tagata (Toho University), Manabu Makinodan (0000-0003-4339-9413, Nara Medical University), Mikio Kido (Toyama City Hospital), Eiichi Katsumoto (0000-0001-9417-4391), Hiroshi Komatsu (0000-0003-3248-7901, Tohoku University Hospital), Junya Matsumoto (0000-0003-4228-3208, National Institute of Mental Health), Chika Kubota (0000-0001-7553-4654, National Center of Neurology and Psychiatry), Kenichiro Miura (0000-0002-3722-7837, National Institute of Mental Health), Akitoyo Hishimoto (0000-0001-9405-8235, Yokohama City University), Koichiro Watanabe (0000-0002-0736-7070, Kyorin University), Ken Inada (0000-0002-3073-4588, Tokyo Women's Medical University), Hiroaki Kawasaki (0000-0002-6945-2107, Fukuoka University), Ryota Hashimoto (0000-0002-5941-4238, National Institute of Mental Health)
Year2022
Volume13
Pages823826-823826
Publication date2022-05-17
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.823826
PMID35656353
OpenAlexW4280568835
LanguageEN
References cited47

In several clinical guidelines for schizophrenia, long-term use of anticholinergic drugs is not recommended. We investigated the characteristics of the use of anticholinergics in patients with schizophrenia by considering psychotropic prescription patterns and differences among hospitals. A cross-sectional, retrospective prescription survey at the time of discharge was conducted on 2027 patients with schizophrenia from 69 Japanese hospitals. We examined the relations among psychotropic drug prescriptions regarding anticholinergic prescription. We divided the hospitals into three groups-low rate group (LG), medium rate group (MG), and high rate group (HG)-according to their anticholinergic prescription rates, and analyzed the relationship between anticholinergic prescription rates and antipsychotic prescription. Anticholinergic drugs were prescribed to 618 patients (30.5%), and the prescription rates were significantly higher for high antipsychotic doses, antipsychotic polypharmacy, and first-generation antipsychotics (FGAs) use. The anticholinergic prescription rate varied considerably among hospitals, ranging from 0 to 66.7%, and it was significantly higher in patients with antipsychotic monotherapy, antipsychotic polypharmacy, and normal and high doses of antipsychotics in HG than in those LG and MG. The anticholinergics prescription rate in patients with second-generation antipsychotic monotherapy in HG was also significantly higher than in those LG and MG; however, the difference was no longer significant in patients with FGA monotherapy. Conclusively, in addition to high antipsychotic doses, antipsychotic polypharmacy, and FGA use, hospital characteristics influence the prescribing of anticholinergic drugs

Anesthesia · Anticholinergic · Antipsychotic · Medical prescription · Polypharmacy · Psychiatry · Schizophrenia (object-oriented programming · Healthcare Decision-Making and Restraints · Medicine · Pharmaceutical Practices and Patient Outcomes · Schizophrenia research and treatment · Internal Medicine · Pharmacology

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