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DNMT gene expression in peripheral leukocytes in schizophrenia and correlations with one-carbon metabolites

Folate, total homocysteine, and vitamin B6

Bibliographic Data

ID15516504
AuthorsYukiko Tomioka (0000-0002-3466-3035, Tokushima University, corresponding author), Masahito Nakataki (0000-0002-4083-6991, Tokushima University), Hidehiro Umehara (0000-0002-2375-8899, Tokushima University), Tomohiro Yoshida (0000-0003-3096-011X, Tokushima University), Hiroya Matsuda (Tokushima University), Yui Matsumoto (0000-0001-9942-9330, Tokushima University), Mariko Aoki (Tokushima University), Yuri Yoshida (Tokushima University), Yuichiro Kamiyama (Tokushima University), Tomohiko Nakayama (Tokushima University), Naoki Yamada (0009-0003-4228-7361, Tokushima University), Shusuke Numata (0009-0009-0697-8871, Tokushima University)
Year2026
Volume16
Pages1715372-1715372
Publication date2026-01-19
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1715372
PMID41635517
OpenAlexW7124767807
LanguageEN
References cited28

These findings suggest a potential correlation between nutritional status and elevated expression of DNMT1 and DNMT3a in schizophrenia. Our findings contribute to the understanding of the epigenetic mechanisms associated with schizophrenia and highlight the need for further investigation of the relationships among gene expression, nutritional status, and psychiatric manifestations

Correlation · DNMT1 · Epigenetics · Gene · Gene expression · Peripheral · Regulation of gene expression · Schizophrenia (object-oriented programming · Vitamin B6 · Epigenetics and DNA Methylation · Folate and B Vitamins Research · Tryptophan and brain disorders

Highly citedNo

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