The interaction effect of high social support and resilience on functional connectivity using seed-based resting-state assessed by 7-Tesla ultra-high field MRI

Bibliographic Data

ID15516705
AuthorsNibal Khudeish (Forschungszentrum Jülich), Shukti Ramkiran (0000-0001-8253-1873, RWTH Aachen University), Dominik Nießen (RWTH Aachen University), Dilsa Cemre Akkoc Altinok (0000-0001-5172-3303, RWTH Aachen University), Ravichandran Rajkumar (0000-0001-5875-5316, Forschungszentrum Jülich), Jürgen Dammers (0000-0003-1526-6592, Forschungszentrum Jülich), N Jon Shah (0000-0002-8151-6169, Jülich Aachen Research Alliance), Tanja Veselinović (0000-0001-7906-6966, RWTH Aachen University), Irene Neuner (0000-0002-5164-8873, Brain (Germany), corresponding author)
Year2024
Volume15
Pages1293514-1293514
Publication date2024-05-20
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2024.1293514
PMID38832325
OpenAlexW4398138842
LanguageEN
Citations received1
References cited35

Recent resilience research has increasingly emphasized the importance of focusing on investigating the protective factors in mentally healthy populations, complementing the traditional focus on psychopathology. Social support has emerged as a crucial element within the complex interplay of individual and socio-environmental factors that shape resilience. However, the neural underpinnings of the relationship between social support and resilience, particularly in healthy subjects, remain largely unexplored. With advances in neuroimaging techniques, such as ultra-high field MRI at 7T and beyond, researchers can more effectively investigate the neural mechanisms underlying these factors. Thus, our study employed ultra-high field rs-fMRI to explore how social support moderates the relationship between psychological resilience and functional connectivity in a healthy cohort. We hypothesized that enhanced social support would amplify resilience-associated connectivity within neural circuits essential for emotional regulation, cognitive processing, and adaptive problem-solving, signifying a synergistic interaction where strong social networks bolster the neural underpinnings of resilience. (n = 30). Through seed-based functional connectivity analyses and interaction analysis, we aimed to uncover the neural correlates at the interplay of social support and resilience. Our findings indicate that perceived social support significantly (p<0.001) alters functional connectivity in the right and left FP, PCC, and left hippocampus, affirming the pivotal roles of these regions in the brain's resilience network. Moreover, we identified significant moderation effects of social support across various brain regions, each showing unique connectivity patterns. Specifically, the right FP demonstrated a significant interaction effect where high social support levels were linked to increased connectivity with regions involved in socio-cognitive processing, while low social support showed opposite effects. Similar patterns by social support levels were observed in the left FP, with connectivity changes in clusters associated with emotional regulation and cognitive functions. The PCC's connectivity was distinctly influenced by support levels, elucidating its role in emotional and social cognition. Interestingly, the connectivity of the left hippocampus was not significantly impacted by social support levels, indicating a unique pattern within this region. These insights highlight the importance of high social support levels in enhancing the neural foundations of resilience and fostering adaptive neurological responses to environmental challenges

Functional connectivity · Physics · Resilience (materials science · Resting state fMRI · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Mental Health Research Topics · Neuroscience · Psychology

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