Reduced Hippocampal Subfield Volume in Schizophrenia and Clinical High-Risk State for Psychosis
Bibliographic Data
| ID | 15517002 |
|---|---|
| Authors | Daiki Sasabayashi (0000-0001-8512-7438, University of Toyama, corresponding author), Ryo Yoshimura (0000-0002-2722-9169, University of Toyama), Tsutomu Takahashi (0000-0002-9335-0776, University of Toyama), Yoichiro Takayanagi (University of Toyama), Shimako Nishiyama (University of Toyama), Yuko Higuchi (0000-0002-3038-4813, University of Toyama), Yuko Mizukami (University of Toyama), Atsushi Furuichi (University of Toyama), Mikio Kido (University of Toyama), Mihoko Nakamura (0000-0002-0910-7774, University of Toyama), Kyo Noguchi (0000-0002-6305-8045, University of Toyama), Michio Suzuki (0000-0001-6150-8957, University of Toyama) |
| Year | 2021 |
| Volume | 12 |
| Pages | 642048-642048 |
| Publication date | 2021-03-22 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.642048 |
| PMID | 33828496 |
| OpenAlex | W3138349624 |
| Language | EN |
| References cited | 98 |
Magnetic resonance imaging (MRI) studies in schizophrenia demonstrated volume reduction in hippocampal subfields divided on the basis of specific cytoarchitecture and function. However, it remains unclear whether this abnormality exists prior to the onset of psychosis and differs across illness stages. MRI (3 T) scans were obtained from 77 patients with schizophrenia, including 24 recent-onset and 40 chronic patients, 51 individuals with an at-risk mental state (ARMS) (of whom 5 subsequently developed psychosis within the follow-up period), and 87 healthy controls. Using FreeSurfer software, hippocampal subfield volumes were measured and compared across the groups. Both schizophrenia and ARMS groups exhibited significantly smaller volumes for the bilateral Cornu Ammonis 1 area, left hippocampal tail, and right molecular layer of the hippocampus than the healthy control group. Within the schizophrenia group, chronic patients exhibited a significantly smaller volume for the left hippocampal tail than recent-onset patients. The left hippocampal tail volume was positively correlated with onset age, and negatively correlated with duration of psychosis and duration of medication in the schizophrenia group. Reduced hippocampal subfield volumes observed in both schizophrenia and ARMS groups may represent a common biotype associated with psychosis vulnerability. Volumetric changes of the left hippocampal tail may also suggest ongoing atrophy after the onset of schizophrenia
Abnormality · Atrophy · Cardiology · Dentate gyrus · Hippocampal formation · Hippocampus · Magnetic resonance imaging · Psychiatry · Psychosis · Radiology · Schizophrenia (object-oriented programming · Subiculum · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment · Internal Medicine
Mapping the Onset of Psychosis
Cortical Surface-Based Analysis
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
Hippocampal Shape and Volume Changes with Antipsychotics in Early Stage Psychotic Illness
Gray Matter Changes in the Insular Cortex During the Course of the Schizophrenia Spectrum
| Citation velocity | historical |
|---|---|
| Highly cited | No |