BDNF genetic variants modulate the impact of childhood trauma on symptom dimensions in first-episode schizophrenia
Bibliographic Data
| ID | 15517003 |
|---|---|
| Authors | Junjiao Ping (0009-0001-6454-9444, Wuhan University, corresponding author), Yong Wu (0000-0001-6343-4218, Wuhan University), Jiali Luo (0000-0002-6638-8971, Wuhan University), Ying Zhang (0000-0001-6214-2440, Department of Psychiatry, The Third People’s Hospital of Zhongshan), Yalin Zhang (0000-0003-4341-736X, Wuhan University), Tingyun Jiang (Wuhan University), Yonghui Dang (Xi'an Jiaotong University) |
| Year | 2026 |
| Volume | 17 |
| Pages | 1790184-1790184 |
| Publication date | 2026-03-05 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2026.1790184 |
| PMID | 41868834 |
| OpenAlex | W7134007144 |
| Language | EN |
| References cited | 33 |
These findings demonstrate that BDNF polymorphisms act as genetic modifiers of trauma-related symptom expression, supporting a gene-environment interaction model underlying phenotypic heterogeneity in schizophrenia
Brain-derived neurotrophic factor · CTQ tree · Genetic variants · Neglect · Physical abuse · Positive and Negative Syndrome Scale · Psychological abuse · Schizophrenia (object-oriented programming · Sexual abuse · Child Abuse and Trauma · Nerve injury and regeneration · Posttraumatic Stress Disorder Research
| Highly cited | No |
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