Remission of Persistent Negative Symptoms and Psychosocial Consequences by Combined Clozapine and Cariprazine Treatment in a Patient With Long-Standing Treatment-Resistant Schizoaffective Disorder
Bibliographic Data
| ID | 15517088 |
|---|---|
| Authors | Mats Bogren (0000-0002-1146-9547, Lund University, corresponding author), Monica Soltesz, Stephan Hjorth |
| Year | 2022 |
| Volume | 13 |
| Pages | 887547-887547 |
| Publication date | 2022-05-11 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.887547 |
| PMID | 35664491 |
| OpenAlex | W4280567063 |
| Language | EN |
| Citations received | 1 |
| References cited | 22 |
This patient case report describes a 45-year old white unmarried man with disability pension due to schizoaffective disorder, diagnosed at the age of 24. He lives in an apartment and has housing support. Retrospectively, the patient displayed prodromal markers of a disorder within the schizophrenia spectrum many years before the onset of frank psychosis, indeed since childhood. Over the years several symptoms and signs across schizophrenia domains have been manifest: positive, negative, cognitive, and affective, among which the negative and affective symptoms and signs were the earliest to appear. While the positive, disorganized, and catatonic symptoms responded to treatment - when duly tested and complied with - the negative and affective symptoms have been notoriously difficult to handle. We now report on the successful introduction of cariprazine (CAR) to his ongoing clozapine (CLZ) medication, the result of which has been a near-complete remission of his persistent negative and psychosocial issues. We interpret this remarkable alleviation of the patient's disease - and concomitant improvement of his quality of life - in terms of neuroreceptor target complementarity between CLZ and CAR, with particular emphasis on the contributions from the D3 and D2 receptor partial agonist components of the latter agent
Clozapine · Psychiatry · Psychosis · Psychosocial · Schizoaffective disorder · Schizophrenia (object-oriented programming · Bipolar Disorder and Treatment · Clinical Psychology · Electroconvulsive Therapy Studies · Medicine · Psychology · Schizophrenia research and treatment · Pediatrics
| Citations per year | 0.5 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |