Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach
Bibliographic Data
| ID | 15517291 |
|---|---|
| Authors | Maria Anayali Estudillo‐Guerra (0000-0002-2442-652X, Massachusetts General Hospital), Maria Anayali Estudillo-Guerra, Clas Linnman (0000-0001-8449-894X, Spaulding Rehabilitation Hospital), Víctor Gálvez (0000-0002-6075-9620, Universidad Panamericana), Gina Chapa-Koloffon (0000-0001-8726-628X, Hospital Infantil de México Federico Gómez), Kevin Pacheco‐Barrios (0000-0002-7166-2816, Spaulding Rehabilitation Hospital), Kevin Pacheco-Barrios, León Morales-Quezada (0000-0003-0736-108X, Spaulding Rehabilitation Hospital), Mónica Flores Ramos (Universidad Nacional Autonoma de Mexico, corresponding author) |
| Year | 2023 |
| Volume | 14 |
| Pages | 1244134-1244134 |
| Publication date | 2023-10-04 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2023.1244134 |
| PMID | 37860170 |
| OpenAlex | W4387335763 |
| Language | EN |
| References cited | 47 |
Type I Bipolar disorder (BD-I) is a neuropsychiatric disorder characterized by manic or mixed-featured episodes, impaired cognitive functioning, and persistent work and social functioning impairment. This study aimed to investigate within-subject; (i) differences in brain perfusion using Single-photon emission computed tomography (SPECT) between manic and euthymic states in BD-I patients; (ii) explore potential associations between altered brain perfusion and cognitive status; and (iii) examine the relationship between cerebral perfusion and mania symptom ratings. Seventeen adult patients diagnosed with BD-I in a manic episode were recruited, and clinical assessments, cognitive tests, and brain perfusion studies were conducted at baseline (mania state) and a follow-up visit 6 months later. The results showed cognitive impairment during the manic episode, which persisted during the euthymic state at follow-up. However, no significant changes in brain perfusion were observed between the manic and euthymic states. During mania, trends toward decreased perfusion in the left cerebellum and right superior parietal lobule were noted. Additionally, trends indicated a higher perfusion imbalance in the left superior and middle frontal gyrus during mania and the right superior and middle frontal gyrus during euthymia. No significant correlations existed between brain perfusion, mania symptom ratings, and cognitive performance, indicating that symptomatology might represent more than neural hemodynamics. These findings suggest that cognitive impairment may persist in BD-I patients and highlight the need for therapeutic interventions targeting cognitive deficits. More extensive studies with extended follow-up periods are warranted further to investigate brain perfusion and cognitive functioning in BD-I patients
Audiology · Bipolar disorder · Cardiology · Cerebral perfusion pressure · Cognition · Mania · Mood · Perfusion · Perfusion scanning · Psychiatry · Bipolar Disorder and Treatment · Electroconvulsive Therapy Studies · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment · Internal Medicine
| Highly cited | No |
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