Metabolic Profiling in Bipolar Disorder Patients During Depressive Episodes
Bibliographic Data
| ID | 15517365 |
|---|---|
| Authors | Yan Ren (0000-0001-8854-6283, Shanxi Academy of Medical Sciences), Shuang Bao (Shanxi Academy of Medical Sciences), Yuan Jia (0000-0002-7928-3917, Shanxi Academy of Medical Sciences), Xiaoli Sun (0009-0006-9592-5269, Shanxi Academy of Medical Sciences), Xiao-li Sun, Xiang-xin Cao (Shanxi Academy of Medical Sciences), Xiaoying Bai (0009-0009-9161-8159, Shanxi Academy of Medical Sciences), Xiao-ying Bai, Junsheng Tian (0000-0001-6531-2011, Shanxi University of Traditional Chinese Medicine, corresponding author), Jun-sheng Tian, Hong Yang (0000-0003-1416-0526, Shanxi Academy of Medical Sciences, corresponding author) |
| Year | 2020 |
| Volume | 11 |
| Pages | 569612-569612 |
| Publication date | 2020-12-16 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.569612 |
| PMID | 33391044 |
| OpenAlex | W3112179257 |
| Language | EN |
| Citations received | 3 |
| References cited | 44 |
Bipolar disorder (BD) is a common and debilitating mental disorder. Bipolar depression is the main episode of BD. Furthermore, there are no objective biomarkers available for diagnosing the disorder. In this research, a Nuclear Magnetic Resonance (NMR) spectroscopy based on a metabonomics technique was used to analyze serum samples from 37 patients with bipolar depression and 48 healthy control participants to determine potential biomarkers for bipolar depression. In total, seven different metabolites were identified that could effectively distinguish patients from healthy controls. The metabolites indicated that disturbances of amino acid and energy metabolisms might be involved in the pathogenesis of BD. Finally, a panel consisting of four potential biomarkers (lactate, trimethylamine oxide, N-acetyl glycoprotein, and α-glucose) was identified, which showed a higher combined diagnostic ability with an area under the curve of 0.893. Our findings may contribute to the development of an objective method for diagnosing bipolar depression
Bipolar disorder · Bipolar II disorder · Depression (economics · Lithium (medication · Psychiatry · Bipolar Disorder and Treatment · Clinical Psychology · Electrolyte and hormonal disorders · Medicine · Psychology · Tryptophan and brain disorders · Internal Medicine
Comparing the metabolic pathways of different clinical phases of bipolar disorder through metabolomics studies
Search for serum biomarkers in patients with bipolar disorder and major depressive disorder using metabolome analysis
Pre- and Post-treatment Levels of Plasma Metabolites in Patients With Bipolar Depression
| Unique citing works | 3 |
|---|---|
| Citations per year | 0.6 |
| Citation span | 2021 - 2024 (4) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 3 |