Serum Levels of Vitamin A and Vitamin D and Their Association With Symptoms in Children With Attention Deficit Hyperactivity Disorder
Bibliographic Data
| ID | 15517546 |
|---|---|
| Authors | Honghua Li (0000-0001-6243-3862, Jilin University), Hong-Hua Li, Xiaojing Yue (0000-0002-3385-3857, Jilin University), Xiao-Jing Yue, Chengxin Wang (0000-0001-7942-4508, Jilin University), Cheng-Xin Wang, Junyan Feng (First Hospital of Jilin University), Jun-Yan Feng, Bing Wang (0000-0001-5106-6681, Jilin University), Feiyong Jia (0000-0002-8309-1395, Jilin University, corresponding author), Fei-Yong Jia |
| Year | 2020 |
| Volume | 11 |
| Pages | 599958-599958 |
| Publication date | 2020-11-23 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.599958 |
| PMID | 33329153 |
| OpenAlex | W3106763103 |
| Language | EN |
| Citations received | 1 |
| References cited | 45 |
Objective: To measure levels of vitamin A (VA) and vitamin D (VD) and the symptomatic association of their co-deficiencies on attention deficit hyperactivity disorder (ADHD) in Chinese children (6-9 years). Methods: Eighty-two children (69 boys and 13 girls; mean age = 7.1 ± 0.9 years at the time of the diagnosis) with ADHD were recruited as ADHD group. A total of 106 healthy children were recruited as the healthy control (HC) group. Serum levels of retinol and 25-hydroxyvitamin D (25(OH)D) of all children were evaluated using high-performance liquid chromatography (HPLC) and HPLC-tandem mass spectrometry. The Swanson, Nolan, and Pelham IV Rating Scale (SNAP-IV) was employed to assess the clinical symptoms of ADHD. Results: Children suffering from ADHD had significantly reduced serum levels of retinol and 25(OH)D compared with those of HCs, and the prevalence of VA deficiency and VD deficiency were higher in children suffering from ADHD. Serum concentrations of 25(OH)D and retinol were linked closely with the presence or absence of ADHD after adjustment for age, body mass index, season of blood sampling, and sun exposure. Serum concentrations of 25(OH)D and retinol showed a negative correlation with the total scores of SNAP-IV. Children with ADHD as well as VA and VD co-deficiency had increased SNAP-IV total scores and ADHD inattention subscale scores. Conclusion: VA deficiency and VD deficiency in children with ADHD were increased in comparison with that in HCs. VA and VD co-deficiency associated with ADHD symptom severity. Attention should be paid to regular testing of VA levels and VD levels. However, the mechanism of VA and VD in ADHD needs to be further studied. Interventional studies on VA and VD supplementation are recommended to further verify the relationship between VA and VD co-deficiency and ADHD
Blood sampling · Body mass index · Psychiatry · Vitamin D and neurology · vitamin D deficiency · Attention Deficit Hyperactivity Disorder · Biotin and Related Studies · Children's Physical and Motor Development · Medicine · Internal Medicine · Pediatrics
Prevalence of Attention-Deficit/Hyperactivity Disorder
The age-dependent decline of attention deficit hyperactivity disorder
Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents
Psychometric properties of the Chinese version of the Swanson, Nolan, and Pelham, version IV scale – parent form
Clinical Relevance of the Primary Findings of the MTA
Evaluation, Treatment, and Prevention of Vitamin D Deficiency
Reduced Prefrontal Gyrification in Carriers of the Dopamine D4 Receptor 7-Repeat Allele With Attention Deficit/Hyperactivity Disorder
Micronutrients and Diets in the Treatment of Attention-Deficit/Hyperactivity Disorder
Epigenetics and Attention-Deficit/Hyperactivity Disorder
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |