Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid

Bibliographic Data

ID15517669
AuthorsHui Li (0000-0001-9355-1116, Second Affiliated Hospital of Xinjiang Medical University), Qingshuang Mu (Xinjiang Medical University), Yimin Kang (Inner Mongolia Medical University), Xiaoyu Yang (0000-0003-1273-6085, Peking University), Ligang Shan (0000-0002-7886-4322, The Second Affiliated Hospital of Xiamen Medical College), Meiling Wang (0000-0001-5781-4839, Inner Mongolia Medical University), Cunbao Li (0000-0003-3323-9221, Inner Mongolia Medical University), Yanlong Liu (0000-0002-5254-3897, Wenzhou Medical University, corresponding author), Fan Wang (0000-0002-9869-9504, Peking University, corresponding author)
Year2021
Volume12
Pages738358-738358
Publication date2021-11-19
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2021.738358
PMID34887785
OpenAlexW3216140969
LanguageEN
References cited68

Objective: Cigarette smoking might accelerate cognitive impairment; however, this has never been investigated using human cerebrospinal fluid (CSF). We conducted this study to investigate the association between cigarette smoking and cognitive impairment through metal ions in CSF. Methods: We obtained 5-ml CSF samples from routine lumbar puncture procedures in patients undergoing anterior cruciate ligament reconstruction before surgery in China. A total of 180 Chinese males were recruited (80 active smokers and 100 non-smokers). We measured specific cigarette-related neurotoxic metal ions in CSF, including iron, copper, zinc, lead, aluminum, and manganese. Sociodemographic data and history of smoking were obtained. The Montreal Cognitive Assessment (MoCA) was applied. Results: Active smokers had fewer years of education (11.83 ± 3.13 vs. 13.17 ± 2.60, p = 0.01), and higher age (33.70 ± 10.20 vs. 29.76 ± 9.58, p = 0.01) and body mass index (25.84 ± 3.52 vs. 24.98 ± 4.06, p =0.03) than non-smokers. Compared to non-smokers, active smokers had significantly higher CSF levels of iron, zinc, lead, and aluminum and lower MoCA scores (all p r = -0.244, p = 0.048). In young smokers, CSF manganese levels negatively correlated with MoCA scores ( r = -0.373, p = 0.009). Conclusions and Relevance: Cigarette smoking might be associated with male cognitive impairment, as shown by lower MoCA scores and higher levels of CSF iron, zinc, lead, and aluminum in active smokers. This might be early evidence of cigarette smoking accelerating male cognitive impairment

Body mass index · Cerebrospinal fluid · Cigarette smoking · Cognitive impairment · Disease · Montreal Cognitive Assessment · Medicine · Trace Elements in Health · Gastroenterology · Internal Medicine

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