Case Report
Anti-N-Methyl-D-Aspartate Receptor Encephalitis Manifesting With an Isolated Psychiatric Episode and Normal Ancillary Tests
Bibliographic Data
| ID | 15517694 |
|---|---|
| Authors | Denis Pavăl (0000-0003-0532-586X, Iuliu Hațieganu University of Medicine and Pharmacy, corresponding author), Claudia Mihaela Cîmpan, Nicoleta Gherghel (0000-0001-7205-628X, Clinical Emergency Hospital Bucharest), Laura Damian (0000-0002-5735-3929), Nicoleta Tohǎnean (Iuliu Hațieganu University of Medicine and Pharmacy), I Micluția (0000-0003-2478-0876, Iuliu Hațieganu University of Medicine and Pharmacy) |
| Year | 2022 |
| Volume | 13 |
| Pages | 905088-905088 |
| Publication date | 2022-06-02 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.905088 |
| PMID | 35722579 |
| OpenAlex | W4281873986 |
| Language | EN |
| References cited | 1 |
The majority of patients with anti-N-Methyl-D-Aspartate receptor (NMDAR) encephalitis present with psychiatric symptoms and subsequently develop neurological features. However, isolated psychiatric episodes occur in <5% of affected individuals, less frequent at disease onset (<1%) compared to relapse (4%). We report the case of a previously healthy 24-year-old female who presented with psychotic symptoms and behavioral alterations. Despite therapy, she showed no improvement and subsequently developed catatonic features. While the ancillary tests were normal, the clinical warning signs raised the suspicion of anti-NMDAR encephalitis which we later confirmed. Given its strong association with underlying tumors, we screened the patient and found an ovarian teratoma. Once removed, the patient displayed a substantial improvement in the mental status. Besides being extremely rare, this case illustrates the need to maintain clinical suspicion of anti-NMDAR encephalitis even in the absence of neurological features or paraclinical anomalies
Autoimmune encephalitis · Disease · Encephalitis · Ovarian Teratoma · Pathology · Psychiatry · Teratoma · Virus · Autoimmune Neurological Disorders and Treatments · Medicine · Peripheral Neuropathies and Disorders · Polyomavirus and related diseases · Immunology · Internal Medicine · Pediatrics
| Highly cited | No |
|---|