Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness
Bibliographic Data
| ID | 15517985 |
|---|---|
| Authors | Ulrika Hylén (0000-0003-0547-4398, Örebro University, corresponding author), Aidan McGlinchey (0000-0001-6682-6030, Örebro University), Matej Orešič (0000-0002-2856-9165, Örebro University), Susanne Bejerot (0000-0002-3587-6075, Örebro University), Mats B Humble (0000-0001-6726-7787, Örebro University), Eva Särndahl (0000-0002-4319-7208, Örebro University), Tuulia Hyötyläinen (0000-0002-1389-8302, Örebro University), Daniel Eklund (0000-0002-6045-4800, Örebro University) |
| Year | 2021 |
| Volume | 12 |
| Pages | 778325-778325 |
| Publication date | 2021-11-26 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.778325 |
| PMID | 34899431 |
| OpenAlex | W3217582672 |
| Language | EN |
| References cited | 63 |
Mental disorders are heterogeneous and psychiatric comorbidities are common. Previous studies have suggested a link between inflammation and mental disorders. This link can manifest as increased levels of proinflammatory mediators in circulation and as signs of neuroinflammation. Furthermore, there is strong evidence that individuals suffering from psychiatric disorders have increased risk of developing metabolic comorbidities. Our group has previously shown that, in a cohort of low-functioning individuals with serious mental disorders, there is increased expression of genes associated with the NLRP3 inflammasome, a known sensor of metabolic perturbations, as well as increased levels of IL-1-family cytokines. In the current study, we set out to explore the interplay between disease-specific changes in lipid metabolism and known markers of inflammation. To this end, we performed mass spectrometry-based lipidomic analysis of plasma samples from low-functioning individuals with serious mental disorders ( n = 39) and matched healthy controls ( n = 39). By identifying non-spurious immune-lipid associations, we derived a partial correlation network of inflammatory markers and molecular lipids. We identified levels of lipids as being altered between individuals with serious mental disorders and controls, showing associations between lipids and inflammatory mediators, e.g., osteopontin and IL-1 receptor antagonist. These results indicate that, in low-functioning individuals with serious mental disorders, changes in specific lipids associate with immune mediators that are known to affect neuroinflammatory diseases
Inflammation · Mental health · Mental illness · Psychiatry · Psychotherapist · Clinical Psychology · Health, psychology, and well-being · Inflammasome and immune disorders · Medicine · Psychology · Tryptophan and brain disorders · Internal Medicine
Diagnostic and Statistical Manual of Mental Disorders
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016
The role of inflammation in depression
A Brief Mental Health Outcome Scale
Estimating the true global burden of mental illness
Developing the World Health Organization Disability Assessment Schedule 2.0
A Simple Method for the Isolation and Purification of Total Lipides From Animal Tissues
The PHQ-9
Lipidomics in Major Depressive Disorder
Elevated Osteopontin and Interferon Gamma Serum Levels and Increased Neutrophil-to-Lymphocyte Ratio Are Associated With the Severity of Symptoms in Schizophrenia
| Highly cited | No |
|---|