From Toxoplasmosis to Schizophrenia via NMDA Dysfunction
Peptide Overlap between Toxoplasma gondii and N-Methyl-d-Aspartate Receptors As a Potential Mechanistic Link
Bibliographic Data
| ID | 15518058 |
|---|---|
| Authors | Guglielmo Lucchese (0000-0002-1809-6376, Freie Universität Berlin, corresponding author) |
| Year | 2017 |
| Volume | 8 |
| Pages | 37-37 |
| Publication date | 2017-03-15 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2017.00037 |
| PMID | 28360866 |
| OpenAlex | W2597906971 |
| Language | EN |
| Citations received | 1 |
| References cited | 79 |
The present work aims at investigating how Toxoplasma gondii ( T. gondii ) infection may be linked to N -methyl-d-aspartate receptor (NMDAR) dysfunction in schizophrenia and related disorders and puts forward the hypothesis that immune responses against T. gondii may involve NMDARs. Indeed, the analysis of the protozoan proteome and NMDAR subunits for peptide commonalities shows a massive peptide overlap and supports the possibility that anti- T. gondii immune responses raised during active protozoan infection may cross-react with host NMDARs, determining disruption of neural circuits and cognitive deficits. In particular, the NMDA 2D subunit, which is mainly expressed in parvalbumin-positive interneurons, appears to be a hotspot for potential T. gondii -induced cross-reactive immune attacks
Antibody · Biology · NMDA receptor · Psychiatry · Receptor · Schizophrenia (object-oriented programming · Toxoplasma gondii · Toxoplasmosis · Biochemical effects in animals · Medicine · Neuroscience · Neuroscience and Neuropharmacology Research · Psychology · Tryptophan and brain disorders · Immunology · Internal Medicine
| Citations per year | 0.17 |
|---|---|
| Citation span | 2020 - 2020 (1) |
| Highly cited | No |