A New Division of Schizophrenia Revealed Expanded Bilateral Brain Structural Abnormalities of the Association Cortices
Bibliographic Data
| ID | 15518103 |
|---|---|
| Authors | István Szendi (0000-0002-2612-7291, University of Szeged, corresponding author), Nikoletta Szabó (0000-0003-1656-5121, University of Szeged), Nóra Domján (University of Szeged), Zsigmond Tamás Kincses (0000-0002-1442-4475, University of Szeged), András Palkó (0000-0002-5370-6934, University of Szeged), László Vécsei (0000-0001-8037-3672, Hungarian Academy of Sciences), Mihály Racsmány (0009-0006-6591-7233, Budapest University of Technology and Economics) |
| Year | 2017 |
| Volume | 8 |
| Pages | 127-127 |
| Publication date | 2017-07-20 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2017.00127 |
| PMID | 28775696 |
| OpenAlex | W2738385515 |
| Language | EN |
| References cited | 48 |
The phenomenological and, consequently, pathophysiological heterogeneity of schizophrenia may be substantially decreased by determining etiologically valid subgroups. In a cross-sectional study, we analyzed the brain structural impairments of outpatients with schizophrenia using concurrent subgrouping methods, partly to enhance the extensity of exploration, and partly to estimate the validation of the divisions. High resolution T1-weighted MR images were obtained for 21 patients and 13 healthy controls. Localized gray matter volumetric deficits were defined with optimized voxel-based morphometry. Employing two concurrent methods (i.e., the widely known deficit-non-deficit division vs. the neurocognitive clusters we identified earlier) the patient group was iteratively divided into two subgroups, and their volumetric peculiarities were compared with one another and with healthy controls. Our division revealed more significant differences demonstrating bilateral brain structural deficits, which affected the association cortices, primarily the heteromodal fields and partly the unimodal fields. This is the first study that showed that abnormalities of the association cortices can be bihemispherial and expanded in schizophrenia, even in the cases of outpatients living integrated in society. Our result suggests that the extended association cortex abnormalities could constitute substantial and determining neurological substrates in the phenomenology and aetiopathogenesis of schizophrenia, at least in a subgroup of patients with more unfavorable neurocognitive characteristics
Association (psychology · Cognition · Neurocognitive · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Voxel · Advanced MRI Techniques and Applications · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology
Threshold-free cluster enhancement
A global optimisation method for robust affine registration of brain images
Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm
Fast robust automated brain extraction
Voxel-Based Morphometry—The Methods
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
| Highly cited | No |
|---|