Biomarker Case-Detection and Prediction with Potential for Functional Psychosis Screening
Development and Validation of a Model Related to Biochemistry, Sensory Neural Timing and End Organ Performance
Bibliographic Data
| ID | 15518378 |
|---|---|
| Authors | Stephanie Fryar-Williams (0000-0001-5397-5459, Basil Hetzel Institute, corresponding author), Jörg Strobel (The University of Adelaide), Jörg E Strobel |
| Year | 2016 |
| Volume | 7 |
| Pages | 48-48 |
| Publication date | 2016-04-14 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2016.00048 |
| PMID | 27148083 |
| OpenAlex | W2339196625 |
| Language | EN |
| Citations received | 1 |
| References cited | 73 |
The Mental Health Biomarker Project aimed to discover case-predictive biomarkers for functional psychosis. In a retrospective, cross-sectional study, candidate marker results from 67 highly characterized symptomatic participants were compared with results from 67 gender- and age-matched controls. Urine samples were analyzed for catecholamines, their metabolites, and hydroxylpyrolline-2-one, an oxidative stress marker. Blood samples were analyzed for vitamin and trace element cofactors of enzymes in catecholamine synthesis and metabolism pathways. Cognitive, auditory, and visual processing measures were assessed using a simple 45-min, office-based procedure. Receiver operating curve (ROC) and odds ratio analysis discovered biomarkers for deficits in folate, vitamin D and B6 and elevations in free copper to zinc ratio, catecholamines and the oxidative stress marker. Deficits were discovered in peripheral visual and auditory end-organ function, intracerebral auditory and visual processing speed and dichotic listening performance. Fifteen ROC biomarker variables were divided into five functional domains. Through a repeated ROC process, individual ROC variables, followed by domains and finally the overall 15 set model, were dichotomously scored and tallied for abnormal results upon which it was found that ≥3 out of 5 abnormal domains achieved an area under the ROC curve of 0.952 with a sensitivity of 84% and a specificity of 90%. Six additional middle ear biomarkers in a 21 biomarker set increased sensitivity to 94%. Fivefold cross-validation yielded a mean sensitivity of 85% for the 15 biomarker set. Non-parametric regression analysis confirmed that ≥3 out of 5 abnormally scored domains predicted >50% risk of caseness while 4 abnormally scored domains predicted 88% risk of caseness; 100% diagnostic certainty was reached when all 5 domains were abnormally scored. These findings require validation in prospective cohorts and other mental illness states. They have potential for case-detection, -screening, -monitoring, and -targeted personalized management. The findings unmask unmet needs within the functional psychosis condition and suggest new biological understandings of psychosis phenomenology
Area under the curve · Audiology · Biology · Biomarker · Receiver operating characteristic · Functional Brain Connectivity Studies · Medicine · Olfactory and Sensory Function Studies · Tryptophan and brain disorders · Biochemistry · Internal Medicine · Oncology
Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves
Locally Weighted Regression
Dissociation Between Reactivity of the Hypothalamus-Pituitary-Adrenal Axis and the Sympathetic-Adrenal-Medullary System to Repeated Psychosocial Stress
Peripheral catecholamine levels and the symptoms of anxiety
| Citations per year | 0.1 |
|---|---|
| Citation span | 2016 - 2016 (1) |
| Highly cited | No |