Cortical Gray Matter Loss, Augmented Vulnerability to Speech-on-Speech Masking, and Delusion in People With Schizophrenia
Bibliographic Data
| ID | 15518970 |
|---|---|
| Authors | Chao Wu (0000-0002-3490-1435, Beijing Normal University), Yingjun Zheng (0000-0002-6336-4827, Guangzhou Psychiatric Hospital), Juanhua Li (Guangzhou Medical University), Shenglin She (Guangzhou Medical University), Hongjun Peng (0000-0002-9115-7374, Guangzhou Medical University), Liang Li (0000-0002-1688-1143, Chinese Institute for Brain Research, corresponding author) |
| Year | 2018 |
| Volume | 9 |
| Pages | 287-287 |
| Publication date | 2018-07-04 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00287 |
| PMID | 30022955 |
| OpenAlex | W2807971382 |
| Language | EN |
| Citations received | 1 |
| References cited | 65 |
People with schizophrenia exhibit impairments in target-speech recognition (TSR) against multiple-talker-induced informational speech masking. Up to date, the underlying neural mechanisms and its relationships with psychotic symptoms remain largely unknown. This study aimed to investigate whether the schizophrenia-associated TSR impairment contribute to certain psychotic symptoms by sharing underlying alternations in cortical gray-matter volume (GMV) with the psychotic symptoms. Participants with schizophrenia ( N = 34) and their matched healthy controls ( N = 29) were tested for TSR against a two-talker-speech masker. Psychotic symptoms of participants with schizophrenia were evaluated using the Positive and Negative Syndrome Scale. The regional GMV across various cortical regions was assessed using the voxel-based morphometry. The results of partial-correlation and mediation analyses showed that in participants with schizophrenia, the TSR was negatively correlated with the delusion severity, but positively with the GMV in the bilateral superior/middle temporal cortex, bilateral insular, left medial orbital frontal gyrus, left Rolandic operculum, left mid-cingulate cortex, left posterior fusiform, and left cerebellum. Moreover, the association between GMV and delusion was based on the mediating role played by the TSR performance. Thus, in people with schizophrenia, both delusions and the augmented vulnerability of TSR to informational masking are associated with each other and share the underlying cortical GMV reduction, suggesting that the origin of delusion in schizophrenia may be related to disorganized or limited informational processing (e.g., the incapability of adequately filtering information from multiple sources at the perceptual level). The TSR impairment can be a potential marker for predicting delusion severity
Audiology · Auditory hallucination · Cognition · Delusion · Prefrontal cortex · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Temporal cortex · Temporoparietal junction · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |