A randomized controlled trial of adjunctive iTBS targeting the dorsomedial prefrontal cortex for anhedonia in schizophrenia
Rationale and protocol design
Bibliographic Data
| ID | 15519154 |
|---|---|
| Authors | Hao Wu (0000-0001-5323-516X, Affiliated Hospital of Southwest Medical University), Mei Yu (0000-0002-0283-9649, Affiliated Hospital of Southwest Medical University), Yuke He (0000-0002-6716-198X, Affiliated Hospital of Southwest Medical University), Wenzhong Liu (0000-0003-0474-0770, Affiliated Hospital of Southwest Medical University), Fan Yang (0000-0003-2978-7102, Affiliated Hospital of Southwest Medical University), Yang Fan (0009-0004-1290-4418), Wei Xu (0000-0002-4727-1540), Han Den, Long Yun (0000-0001-7304-1231, Zigong First People's Hospital), Yun Long (0000-0003-4228-8471), Bo Liu (0000-0002-6536-517X, Zigong Light Industry Design Institute (China), corresponding author), Kezhi Liu (0000-0003-4515-4209, Affiliated Hospital of Southwest Medical University, corresponding author), Youguo Tan (0000-0002-4892-3758, Affiliated Hospital of Southwest Medical University, corresponding author) |
| Year | 2025 |
| Volume | 16 |
| Pages | 1706553-1706553 |
| Publication date | 2025-11-24 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1706553 |
| PMID | 41367943 |
| OpenAlex | W4416593550 |
| Language | EN |
| References cited | 41 |
If the iTBS protocols targeting the DMPFC lead to positive changes in anhedonia symptoms in patients with schizophrenia, this would provide a new intervention strategy for negative symptoms. Furthermore, leveraging neuroimaging evidence from such studies could help optimize rTMS target selection and overall treatment strategies.Trial registration: ChiCTR2500107965
Anhedonia · Functional magnetic resonance imaging · Intervention (counseling · Neuroimaging · Prefrontal cortex · Protocol (science · Randomized controlled trial · Transcranial magnetic stimulation · Functional Brain Connectivity Studies · Neurotransmitter Receptor Influence on Behavior · Transcranial Magnetic Stimulation Studies
| Citation velocity | historical |
|---|---|
| Highly cited | No |