Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder
Bibliographic Data
| ID | 15519322 |
|---|---|
| Authors | Sara Poletti (0000-0001-9594-0246, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele), Mario Gennaro Mazza (0000-0001-6613-2477, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele), Benedetta Vai (0000-0002-0748-4656, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele), Cristina Lorenzi (0000-0002-3324-1359, Istituti di Ricovero e Cura a Carattere Scientifico), Cristina Colombo (0000-0001-7310-7341, Vita-Salute San Raffaele University), Francesco Benedetti (0000-0003-4949-856X, Vita-Salute San Raffaele University, corresponding author) |
| Year | 2020 |
| Volume | 11 |
| Pages | 590095-590095 |
| Publication date | 2020-12-08 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.590095 |
| PMID | 33363485 |
| OpenAlex | W3112315774 |
| Language | EN |
| References cited | 79 |
Bipolar disorder (BD) is a severe psychiatric illness characterized by abnormalities in the immune/inflammatory function and in brain metabolism. Evidences suggest that inflammation may affect the levels of brain metabolites as measured by single-proton magnetic resonance spectroscopy ( 1 H-MRS). The aim of the study was to investigate whether a wide panel of inflammatory markers (i.e., cytokines, chemokines, and growth factors) can predict brain metabolite concentrations of glutamate, myo -inositol, N -acetylaspartate, and glutathione in a sample of 63 bipolar patients and 49 healthy controls. Three cytokines influenced brain metabolite concentrations: IL-9 positively predicts glutamate, IL-1β positively predicts Myo -inositol, and CCL5 positively predicts N -acetylaspartate concentrations. Furthermore, patients showed higher concentrations of glutamate, Myo -inositol, and glutathione and lower concentrations of N -acetylaspartate in respect to healthy controls. Our results confirm that inflammation in BD alters brain metabolism, through mechanisms possibly including the production of reactive oxygen species and glia activation
Glutamate receptor · Glutathione · Inflammation · Metabolite · Proinflammatory cytokine · Receptor · Bipolar Disorder and Treatment · Chemistry · Electrolyte and hormonal disorders · Medicine · Tryptophan and brain disorders · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
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