Brain Functional and Structural Alterations in Women With Bipolar Disorder and Suicidality
Bibliographic Data
| ID | 15519353 |
|---|---|
| Authors | Huiling Guo (0000-0001-6948-5841, China Medical University), Ran Zhang (0000-0001-8483-2565, Nanjing Brain Hospital), Pengshuo Wang (0009-0008-2270-2608, China Medical University), Luheng Zhang (China Medical University), Zhiyang Yin (China Medical University), Yifan Zhang (0000-0002-7236-0799, China Medical University), Shengnan Wei (0000-0002-9075-2200, China Medical University), Miao Chang (0000-0001-8822-4671, China Medical University), Xiaowei Jiang (0000-0001-7320-6462, China Medical University), Yanqing Tang (0000-0002-1331-4936, China Medical University, corresponding author), Fei Wang (0000-0003-0860-6317, China Medical University, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 630849-630849 |
| Publication date | 2021-04-22 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.630849 |
| PMID | 33967852 |
| OpenAlex | W3156723243 |
| Language | EN |
| References cited | 35 |
Objective: Suicide is the leading cause of death from bipolar disorder (BD). At least 25-50% of the patients with BD will attempt suicide, with suicide rates much higher in women patients than in men. It is crucial to explore the potential neural mechanism underlying suicidality in women with BD, which will lead to understanding and detection of suicidality and prevent death and injury from suicide. Methods: Brain function and structure were measured by amplitude of low-frequency fluctuation (ALFF) and gray matter volume (GMV) in 155 women [30 women with BD and a history of suicidality, 50 women with BD without suicidality, and 75 healthy controls (HC)]. The differences in ALFF and GMV across the BD with suicidality, BD without suicidality, and HC groups were investigated. Results: BD with suicidality showed significantly increased ALFF in the left and right cuneus compared with BD without suicidality and HC groups. Moreover, the GMV in the left lateral prefrontal cortex and left cuneus in BD with suicidality were significantly lower than those in BD without suicidality and HC groups, while the GMV of the right ventral prefrontal cortex was significantly decreased in both BD with and without suicidality groups. Conclusions: This study, combining functional and structural neuroimaging techniques, may help to identify specific pathophysiological changes in women with BD and suicidality. Increased ALFF and less GMV in cuneus might represent the neuroimaging features of suicidality in women with BD. Investigating this potential neuromarker for suicidality in women with BD may lead to the ability to prevent suicidality
Bipolar disorder · Cognition · Cuneus · Medical emergency · Mood · Neuroimaging · Poison control · Precuneus · Prefrontal cortex · Psychiatry · Suicidal ideation · Suicide prevention · Bipolar Disorder and Treatment · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Psychology · Suicide and Self-Harm Studies
| Citation velocity | historical |
|---|---|
| Highly cited | No |