Callous-Unemotional Traits Moderate the Relationship Between Irritability and Threatening Responding
Bibliographic Data
| ID | 15519371 |
|---|---|
| Authors | Ru Zhang (0000-0002-4860-7800, Boys Town, corresponding author), Johannah Bashford-Largo (0000-0002-0128-9526, Boys Town), Jennie Lukoff (Boys Town), Jaimie Elowsky (0000-0001-7995-3725, Boys Town), Erin Carollo (0000-0002-7341-9123, Boys Town), Amanda Schwartz (Boys Town National Research Hospital), Matthew Dobbertin (0000-0003-4556-5892, Boys Town National Research Hospital), Sahil Bajaj (0000-0003-0629-6036, Boys Town National Research Hospital), Karina S Blair (0000-0003-4382-6219, Boys Town), Ellen Leibenluft (0000-0001-8971-2087, National Institutes of Health), James Blair (0000-0002-6377-2361, Boys Town), R James R Blair |
| Year | 2021 |
| Volume | 12 |
| Pages | 617052-617052 |
| Publication date | 2021-11-16 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.617052 |
| PMID | 34867494 |
| OpenAlex | W3214029882 |
| Language | EN |
| References cited | 68 |
Background: Irritability and callous-unemotional (CU; reduced guilt/empathy) traits vary dimensionally in the typically developing population but may be particularly marked in youth with conduct disorder (CD). While these dimensional traits are positively correlated, they have been associated with divergent forms of dysfunction, particularly with respect to threat processing (i.e., irritability with increased, and CU traits with decreased, threat responsiveness). This suggests that interactions between these two dimensions may be complex at the neurobiological level. However, this issue has received minimal empirical attention. Methods: The study included 105 adolescents (typically developing and cases with CD; N = 59). They were scanned with fMRI during a looming threat task that involved images of threatening and neutral human faces or animals that appeared to be either looming or receding. Results: Significant irritability-by-CU traits-by-Direction-by-Emotion interactions were seen within right thalamus/PAG, left lingual gyrus and right fusiform gyrus; irritability was positively associated with the BOLD response for Looming Threatening vs. Receding Threatening trials, particularly for youth with low CU traits. In contrast, CU traits were negatively associated with the same differential BOLD response but particularly for youth showing higher levels of irritability. Similar findings were seen within left ventral anterior and posterior cingulate cortices, though the addition of the interaction with CU traits was only seen at slightly more lenient thresholds. Conclusions: The results support previous work linking irritability to increased, and CU traits to reduced, threat responsiveness. However, for adolescents with high irritability, if CU traits are also high, the underlying neuropathology appears to relate to reduced, rather than increased, threat responsiveness
Aggression · Cognition · Cognitive psychology · Developmental psychology · Empathy · Irritability · Looming · Psychiatry · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Neuroscience · Personality Disorders and Psychopathology · Psychology · Psychopathy, Forensic Psychiatry, Sexual Offending
Affective Neuroscience
The normative development of emotion regulation strategy use in children and adolescents
Positive and Negative Emotion Regulation in Adolescence
Toward the future of psychiatric diagnosis
Annual Research Review
Callous-Unemotional Traits in a Community Sample of Adolescents
Emotion regulation from early adolescence to emerging adulthood and middle adulthood
An improved brief measure of cannabis misuse
The Nimh Research Domain Criteria (RDoC) Project
Assessing callous–unemotional traits in adolescent offenders
Inventory of Callous–Unemotional Traits
Conduct disorder
The Strengths and Difficulties Questionnaire
SPSS and SAS procedures for estimating indirect effects in simple mediation models
Sexual Abuse in Adolescents Is Associated With Atypically Increased Responsiveness Within Regions Implicated in Self-Referential and Emotional Processing to Approaching Animate Threats
The reactive–proactive aggression questionnaire
Development of the Alcohol Use Disorders Identification Test (Audit)
Tests for comparing elements of a correlation matrix
| Citation velocity | historical |
|---|---|
| Highly cited | No |