Inflammatory Blood Biomarker Kynurenine Is Linked With Elevated Neuroinflammation and Neurodegeneration in Older Adults

Evidence From Two 1H-MRS Post-Processing Analysis Methods

Bibliographic Data

ID15519469
AuthorsWouter A J Vints (0000-0003-1803-4949, Maastricht University, corresponding author), Simona Kušleikienė (0000-0002-3102-0181, Lithuanian Sports University), Samrat Sheoran (0000-0003-2111-0113, Lithuanian Sports University), Milda Šarkinaitė (Lithuanian University of Health Sciences), Kristina Valatkevičienė (Lithuanian University of Health Sciences), Rymantė Gleiznienė (0000-0002-5206-3033, Lithuanian University of Health Sciences), Mindaugas Kvedaras (Lithuanian Sports University), Kazimieras Pukėnas (0000-0002-5764-4443, Lithuanian Sports University), Uwe Himmelreich (0000-0002-2060-8895, KU Leuven), Vida Janina Česnaitienė (0000-0003-0996-0449, Lithuanian Sports University), Oron Levin (0000-0002-9072-5122, KU Leuven), Jeanine Verbunt (0000-0002-9060-9455, Maastricht University), Nerijus Masiulis (0000-0002-2137-4226, Lithuanian Sports University)
Year2022
Volume13
Pages859772-859772
Publication date2022-04-11
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2022.859772
PMID35479493
OpenAlexW4223496916
LanguageEN
References cited96

Our results suggest that serum kynurenine may be used as a peripheral inflammatory marker that is associated with neuroinflammation and neurodegeneration, although not linked to cognition. Future studies should consider longitudinal analysis to assess the causal inferences between chronic peripheral and neuroinflammation, brain structural and neurometabolic changes, and cognitive decline in aging

Anterior cingulate cortex · Biology · Cognition · Cognitive decline · Dementia · Disease · Dorsolateral prefrontal cortex · Functional magnetic resonance imaging · Inflammation · Kynurenine · Kynurenine pathway · Montreal Cognitive Assessment · Neurodegeneration · Neuroinflammation · Posterior cingulate · Prefrontal cortex · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Neuroscience · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Internal Medicine

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