Cardiovascular disease and depression
A bidirectional relationship and its clinical implications
Dados Bibliográficos
| ID | 15519509 |
|---|---|
| Autores | Jianbo Wu (0000-0003-0862-8380, Nanchang University), Zifan Tian (Nanchang University), Zhimin Qi (Nanchang University, autor correspondente), Xia Liu (0000-0003-1136-4742, Jiujiang University, autor correspondente), Xiaoqun Liu (0000-0001-7229-6742), Peng Yu (0000-0002-0402-5390, Nanchang University, autor correspondente) |
| Ano | 2026 |
| Volume | 16 |
| Páginas | 1675680-1675680 |
| Data de publicação | 2026-01-12 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Frontiers in Psychiatry (JOURNAL) |
| Identificadores do periódico | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editora | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1675680 |
| PMID | 41601490 |
| OpenAlex | W7122656595 |
| Idioma | EN |
| Referências citadas | 275 |
There is strong evidence that depression is linked to greater rates of morbidity and death in people with cardiovascular disease (CVD), supporting its status as a key risk factor for the condition. Recent researches suggest a reciprocal relationship, with CVD potentially predisposing people to depressive disorders. Notably, depression has a high comorbidity rate with major cardiovascular disorders such as coronary artery disease and myocardial infarction, which may have a severe impact on patients' long-term outcomes. Several pathways, including neuroendocrine dysregulation, activation of the inflammatory system, and behavioral alterations, appear to underlie the connection between depression and CVD. On the other hand, CVD may lead to the pathophysiology of depression by altering brain hemodynamics and causing blood-brain barrier (BBB) damage. Current therapeutic approaches stress a multimodal approach that combines drug interventions, cognitive behavioral therapy, and lifestyle changes to improve patient results. This review summarizes the latest research findings on the complex connection between depression and cardiovascular diseases, as well as contemporary treatment options and clinical consequences
Cognition · Comorbidity · Coronary artery disease · Depression (economics · Disease · Mechanism (biology · Mortality rate · Risk factor · Cardiac Health and Mental Health · Cardiovascular Health and Risk Factors · Tryptophan and brain disorders
The role of inflammation in depression
Inflammation and Its Discontents
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019
The Bidirectional Relationship of Depression and Inflammation
Exercise as a treatment for depression
Peripheral cytokine and chemokine alterations in depression
Anxious and non-anxious major depressive disorder in the World Health Organization World Mental Health Surveys
Do Depression and Anxiety Mediate the Link Between Educational Attainment and CHD
Association of Anxiety With Resistance Vessel Dysfunction in Human Atherosclerosis
Dynamics of cerebral blood flow following sertraline treatment in adolescent depression
Changes in neurobiological markers of reactivity to alcohol-related stimuli in alcohol-dependent patients after two years of treatment
Predictors of depression among Chinese college students
Effects of a school-based physical activity intervention on mental health indicators in a sample of Brazilian adolescents
Joint association of the inflammatory marker and cardiovascular-kidney-metabolic syndrome stages with all-cause and cardiovascular disease mortality
| Velocidade de citação | historical |
|---|---|
| Altamente citado | Não |