Altered Expression of a Unique Set of Genes Reveals Complex Etiology of Schizophrenia
Dados Bibliográficos
| ID | 15519513 |
|---|---|
| Autores | Ashutosh Kumar (0000-0002-0405-8096, All India Institute of Medical Sciences, autor correspondente), Vikas Pareek (0000-0001-8985-4982, National Brain Research Centre), Himanshu Narayan Singh (0000-0003-4111-5165, Inserm), Muneeb A Faiq (0000-0002-1430-3139, Education and Research Network), Ravi Kant Narayan (0000-0003-2510-6744, All India Institute of Medical Sciences), Khursheed Raza (0000-0002-0455-8306, All India Institute of Medical Sciences), Pavan Kumar (0000-0001-9467-5364, Education and Research Network) |
| Ano | 2019 |
| Volume | 10 |
| Páginas | 906-906 |
| Data de publicação | 2019-12-11 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Frontiers in Psychiatry (JOURNAL) |
| Identificadores do periódico | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editora | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00906 |
| PMID | 31920755 |
| OpenAlex | W3000485294 |
| Idioma | EN |
| Referências citadas | 3 |
Background: The etiology of schizophrenia is extensively debated, and multiple factors have been contended to be involved. A panoramic view of the contributing factors in a genome-wide study can be an effective strategy to provide a comprehensive understanding of its causality. Materials and Methods: GSE53987 dataset downloaded from GEO-database, which comprised mRNA expression data of post-mortem brain tissue across three regions from control (C) and age-matched subjects (T) of schizophrenia (N = Hippocampus [HIP]: C-15, T-18, Prefrontal cortex [PFC]: C-15, T-19, Associative striatum [STR]: C-18, T-18). Bio-conductor-affy-package used to compute mRNA expression, and further t-test applied to investigate differential gene expression. The analysis of the derived genes performed using the PANTHER Classification System and NCBI database. Further, a protein interactome analysis of the derived gene set was performed using STRING v10 database (https://string-db.org/) Results: A set of 40 genes showed significantly altered (p Conclusions: The aberrant expression of genes maintaining basic cell machinery explains compromised neuronal processing in SCZ
Bioinformatics · Biology · Cognition · Computational biology · Gene · Gene expression · Interactome · Prefrontal cortex · Psychiatry · Schizophrenia (object-oriented programming · 14-3-3 protein interactions · Genetics and Neurodevelopmental Disorders · Medicine · Neuroscience · Ubiquitin and proteasome pathways · Genetics
| Velocidade de citação | historical |
|---|---|
| Altamente citado | Não |