Longitudinal Associations of Modifiable Lifestyle Factors With Positive Depression-Screen Over 2.5-Years in an International Cohort of People Living With Multiple Sclerosis
Bibliographic Data
| ID | 15519549 |
|---|---|
| Authors | Keryn L Taylor (0000-0001-7543-4362, The University of Melbourne), Steve Simpson (0000-0001-6521-3056, The University of Melbourne), George A Jelinek (0000-0001-6157-0910, The University of Melbourne, corresponding author), Sandra Neate (0000-0002-0761-9848, The University of Melbourne), Alysha De Livera (0000-0003-4981-4155, The University of Melbourne), Alysha M De Livera, Chelsea R Brown (0000-0002-4168-0319, The University of Melbourne), Emily O’Kearney (0000-0001-6587-0793, The University of Melbourne), Claudia H Marck (0000-0002-3173-1522, The University of Melbourne), Tracey Weiland (0000-0002-4053-5507, The University of Melbourne), Tracey J Weiland |
| Year | 2018 |
| Volume | 9 |
| Pages | 526-526 |
| Publication date | 2018-10-30 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00526 |
| PMID | 30425659 |
| OpenAlex | W2898674233 |
| Language | EN |
| Citations received | 1 |
| References cited | 69 |
Background: Depression is common and has a significant impact on quality of life for many people with multiple sclerosis (MS). A preventive management approach via modification of lifestyle risk factors holds potential benefits. We examined the relationship between modifiable lifestyle factors and depression risk and the change in depression over 2.5 years. Methods: Sample recruited using online platforms. 2,224 (88.9%) at baseline and 1,309 (93.4%) at 2.5 years follow up completed the necessary survey data. Depression risk was measured by the Patient Health Questionnaire-2 (PHQ-2) at baseline and Patient Health Questionniare-9 (PHQ-9) at 2.5-years follow-up. Multivariable regression models assessed the relationships between lifestyle factors and depression risk, adjusted for sex, age, fatigue, disability, antidepressant medication use, and baseline depression score, as appropriate. Results: The prevalence of depression risk at 2.5-years follow-up in this cohort was 14.5% using the PHQ-2 and 21.7% using the PHQ-9. Moderate alcohol intake, being a non-smoker, diet quality, no meat or dairy intake, vitamin D supplementation, omega 3 supplement use, regular exercise, and meditation at baseline were associated with lower frequencies of positive depression-screen 2.5 years later. Moderate alcohol intake was associated with greater likelihood of becoming depression-free and a lower likelihood of becoming depressed at 2.5-years follow-up. Meditating at least once a week was associated with a decreased frequency of losing depression risk, against our expectation. After adjusting for potential confounders, smoking, diet, physical activity, and vitamin D and omega-3 supplementation were not associated with a change in risk for depression. Conclusion: In a large prospective cohort study of people with MS and depression, in line with the emerging treatment paradigm of early intervention, these results suggest a role for some lifestyle factors in depression risk. Further studies should endeavor to explore the impact of positive lifestyle change and improving depression in people living with MS
Anxiety · Cohort · Cohort study · Confounding · Depression (economics · Depressive symptoms · Patient Health Questionnaire · Physical therapy · Psychiatry · Quality of life (healthcare · Demography · Health and Wellbeing Research · Medicine · Multiple Sclerosis Research Studies · Gerontology · Internal Medicine
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |