Decreased Medial Prefrontal Cortex Glutamate Levels in Perimenopausal Women
Bibliographic Data
| ID | 15519618 |
|---|---|
| Authors | Sidney Yap (0000-0002-7364-3715, University of Alberta, corresponding author), Jessica Luki (University of Alberta), Christopher C Hanstock (University of Alberta), Peter Seres (0000-0002-8812-2234, University of Alberta), Tami Shandro (Royal Alexandra Hospital), Sarah Hanstock (University of Alberta), Sarah E C Hanstock, Alynna Lirette, Huaying Zhao (0000-0002-8827-6639, University of Alberta), Katherine J Aitchison (0000-0002-1107-3024, Women and Children’s Health Research Institute), Jean‐Michel Le Mellédo (0000-0002-0454-6698, University of Alberta), Jean-Michel Le Melledo |
| Year | 2021 |
| Volume | 12 |
| Pages | 763562-763562 |
| Publication date | 2021-12-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.763562 |
| PMID | 34966302 |
| OpenAlex | W4200504609 |
| Language | EN |
| Citations received | 1 |
| References cited | 28 |
Objective: There is an increased risk of experiencing depression during perimenopause (PM), a period of rapidly changing female hormone concentrations. Women at particular risk of developing major depression (MD) during PM are those with history of mood sensitivity to female hormone fluctuations i.e., women with a history of premenstrual dysphoric disorder (PMDD) and/or post-partum depression (PPD). Depressive symptomology has been associated with fluctuations of glutamate (Glu) levels in the medial prefrontal cortex (MPFC) in MD patients as well as PMDD and PPD patients. The objective of the study was to compare MPFC Glu levels in healthy perimenopausal and reproductive-aged (RD) women. Methods: Medial prefrontal cortex Glu levels in healthy perimenopausal ( n = 15) and healthy RD women ( n = 16) were compared via Magnetic Resonance Spectroscopy (MRS) scan using a 3 Tesla (T) magnet. Absence of depressive symptomology and psychiatric comorbidity was confirmed via semi-structured interview. Participants were scanned during the early follicular phase (FP) of the menstrual cycle (MC). Results: Mean MPFC Glu concentrations were decreased in the PM group compared to RD group (PM mean = 0.57 ± 0.03, RD mean = 0.63 ± 0.06, t = -3.84, df = 23.97, p = 0.001). Conclusion: Perimenopause is associated with decreases in MPFC Glu levels. This decrease may be contributing to the increased risk of experiencing depression during PM. Further research should assess MPFC Glu levels in perimenopausal women suffering from MD
Cognition · Depression (economics · Glutamate receptor · Hormone · Major depressive disorder · Menstrual cycle · Mood · Prefrontal cortex · Premenstrual dysphoric disorder · Psychiatry · Advanced NMR Techniques and Applications · Biochemical effects in animals · Medicine · Neuroscience and Neuropharmacology Research · Psychology · Endocrinology · Internal Medicine · Physiology
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |