Neurological Soft Signs, Spontaneous and Treatment Emergent Extrapyramidal Syndromes in Black Africans With First Episode Schizophrenia
Bibliographic Data
| ID | 15519629 |
|---|---|
| Authors | Akin Ojagbemi (0000-0001-7612-8017, University of Ibadan, corresponding author), Bonginkosi Chiliza (0000-0001-5417-5920, Stellenbosch University), Bonga Chiliza, Toyin Bello (0000-0002-3121-3290, University of Ibadan), Laila Asmal (0000-0002-6923-6746, Stellenbosch University), Oluyomi Esan (0000-0003-0094-1946, University of Ibadan), Robin Emsley (0000-0003-1250-6888, Stellenbosch University), Oye Gureje (0000-0003-0094-5947, University of Ibadan) |
| Year | 2018 |
| Volume | 9 |
| Pages | 172-172 |
| Publication date | 2018-05-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00172 |
| PMID | 29780333 |
| OpenAlex | W2801527717 |
| Language | EN |
| Citations received | 1 |
| References cited | 27 |
Background: Very little is known about the relationship between spontaneous and treatment-induced motor syndromes in Africans with first episode schizophrenia. Objective: We investigated the association between spontaneous NSS and EPS, with treatment-induced EPS in a homogenous sample of Black Africans with first episode schizophrenia. Methods: We examined Xhosa (South Africa) and Yoruba (Nigeria) patients, using the Neurological Evaluation Scale and extrapyramidal symptoms scale before and at 3 months after exposure to low dose flupenthixol decanoate. Pearson's correlations and Linear regression models, controlling for duration of untreated psychosis (D.U.P) and premorbid adjustments, were used in examining associations. Results: Among 99 participants in the baseline sample, 91 (91.8%) and 20 (20.2%) had at least one definite NSS and EPS, respectively, before exposure to antipsychotics. Treatment-induced EPS were recorded in 34 (38.6%). Spontaneous EPS was associated with treatment-emergent Akathisia in participants with a longer D.U.P ( r = 0.75, β = 0.70, p = 0.008). This association was specific for Parkinsonism ( r = 0.75, β = 0.85, p = 0.008) and dyskinesia ( r = 0.75, β = 1.70, p = 0.008). Conclusion: Similar to previous findings for tardive dyskinesia in studies implementing longer-term follow-up, spontaneous EPS may also predict short-term antipsychotic-induced EPS such as akathisia. These results may be important for early identification of patients at risk of treatment-induced Akathisia-linked psychomotor agitation in first episode schizophrenia
Antipsychotic · Black african · Extrapyramidal symptoms · Psychiatry · Schizophrenia (object-oriented programming · History · Medicine · Mental Health and Psychiatry · Psychology · Psychosomatic Disorders and Their Treatments · Schizophrenia research and treatment · Pediatrics
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |